5-amino-1mq
Price range: $33.24 through $44.00
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99.7% — exceeds 99.00% minimum spec
- Batch
- AM-202607-001
- Test date
- July 23, 2026
- Method
- HPLC + MS
- Lab
-
Bioviridian
College Station, TX
Description
5-Amino-1MQ peptide (5-amino-1-methylquinolinium)
5-amino-1mq peptide Details
5-Amino-1MQ is a small-molecule, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes both nicotinamide (a NAD+ precursor) and the universal methyl donor SAM (S-adenosylmethionine) during its methylation reaction. NNMT expression is elevated in adipose tissue and correlates with metabolic dysfunction, making its inhibition a mechanism of specific interest in metabolic and longevity research. Preclinical studies have examined 5-Amino-1MQ's effect on NNMT activity in adipocytes, where inhibition is associated with increased intracellular NAD+ and SAM availability — both cofactors central to mitochondrial function, sirtuin activity, and methylation-dependent gene regulation. Because NNMT inhibition sits at the intersection of NAD+ metabolism and epigenetic methylation capacity, 5-Amino-1MQ has become a frequently referenced compound in emerging research on adipose-tissue metabolism, weight regulation, and cellular energy homeostasis.
5-amino-1mq peptide Scientific Research
Researchers employ 5-Amino-1MQ in a variety of metabolic and cellular biology models. The following themes summarize key areas of ongoing investigation:
NNMT, NAD⁺, and Energy Metabolism
NNMT catalyzes the methylation of nicotinamide, diverting potential NAD⁺ precursors into alternative metabolites. In multiple preclinical studies, elevated NNMT activity has been associated with altered NAD⁺ pools and changes in cellular energy efficiency, particularly in adipose tissue and liver.
By inhibiting NNMT, 5-Amino-1MQ has been used to study:
- How modulation of NNMT affects NAD⁺ levels in cell lines and animal models
- The downstream impact on mitochondrial respiration and oxidative metabolism
- The relationship between NNMT activity and regulators such as SIRT1, which is widely examined in the context of cellular aging, metabolic control, and stress responses
These investigations are mechanistic in nature and are designed to clarify how NNMT fits into broader metabolic and epigenetic networks.
Adipocyte Biology and Body Mass Models
In rodent models, NNMT expression in adipose tissue has been linked to adipocyte size, lipid accumulation, and changes in energy expenditure. Experimental NNMT inhibition with compounds such as 5-Amino-1MQ has been reported to correlate with:
- Reduced fat cell size and changes in fat mass in diet-induced models
- Shifts in metabolic efficiency and energy utilization
- Altered expression of glucose transporters (including GLUT4) in skeletal muscle and fat tissue
Some studies have observed notable changes in body mass and adipose tissue over relatively short experimental periods without modifications in food intake. These findings are specific to controlled animal models and are used to better understand how NNMT and related pathways influence energy storage and utilization, not to support clinical or therapeutic conclusions.
Muscle Function and Regenerative Research
NNMT is also expressed in skeletal muscle, and 5-Amino-1MQ has been utilized to examine NNMT’s role in muscle energetics and repair. Preclinical investigations in aged animal models have reported that NNMT inhibition may:
- Influence activation of muscle-resident stem cells following injury
- Alter myofiber cross-sectional area and contractile properties
- Interact with NAD⁺-dependent mechanisms implicated in mitochondrial quality and tissue resilience
These findings support the use of 5-Amino-1MQ as a research tool for studying muscle regeneration, sarcopenia models, and age-associated changes in muscle physiology. Any implications for human health remain speculative and unverified.
Neuro-Energetic Pathways and Cognition Research
NAD⁺ is central to neuronal energy metabolism and synaptic function. While 5-Amino-1MQ itself has not been extensively characterized in human neurocognitive contexts, its interaction with NNMT and effects on NAD⁺ pathways have generated interest in:
- Brain energy homeostasis and mitochondrial support in preclinical models
- Neuromuscular junction signaling and synaptic transmission
- How altered NAD⁺ metabolism may relate to age-related cognitive decline in experimental systems
Current research in this area remains exploratory, and 5-Amino-1MQ is used strictly as an investigative tool within laboratory models.
NNMT Expression in Oncology Research
Increased NNMT expression has been documented in several tumor types in preclinical and ex vivo studies, including gastric, pancreatic, renal, and bladder cancer models. Because NNMT is involved in methylation and metabolic control, 5-Amino-1MQ is of interest in:
- Characterizing NNMT as a potential biomarker of tumor metabolism
- Studying how NNMT modulation may influence cancer cell proliferation, redox balance, and methyl-donor utilization
- Evaluating NNMT as a possible experimental target in oncology research
At present, these efforts are confined to laboratory research. 5-Amino-1MQ is not approved for diagnosis, treatment, or prevention of any disease.
Article Titles & Journals
- NAD Metabolism Regulates Proliferation of Macrophages in Atherosclerosis.
- Nicotinamide-N-methyltransferase inhibition improves cardiac function and structure in a h
- Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunctio
- Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome
- Nicotinamide N -methyltransferase promotes M2 macrophage polarization by IL6 and MDSC conv
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Shipping Options
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- We ship Monday through Saturday.
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Order Tracking
- Once your order has shipped, you'll receive a shipping confirmation email with tracking information so you can monitor your delivery.
- Orders totaling $200 or more qualify for FREE UPS 2nd Day Air shipping within the continental United States.
- Free 2nd Day Air shipping does not apply to orders shipping to Puerto Rico, Hawaii, or Alaska.
Handled correctly, stability holds
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
Store vials in a cool, dry place away from heat and direct sunlight.
For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Frequently Asked Questions
PRODUCT & PURITY
This product is offered for laboratory and research use only. It is not intended for human consumption, medical use, therapeutic use, or veterinary use.
Yes, all of our products are sterile and sealed with a sterility plug and safety cap.
Our products undergo quality control internally at our lab and then 3rd party tested at Bioviridian (at their Texas facility) prior to shipment. All of our COA's are then posted on our site immediately upon receipt.
99% or higher. Period. The expected purity is listed on the individual product page or Certificate of Analysis, when available.
No. We are a manufacturing company and because these products are sold for research purposes only, we do not provide dosing, administration, or medical-use guidance.
Unless specifically stated otherwise, these products are not approved by the U.S. Food and Drug Administration for therapeutic or diagnostic use.
STORAGE & STABILITY
As a lyophilized powder, peptides are stable. Delays in shipments up to 7 days will have zero to minimal impact on efficacy of peptides. Most precautionary efforts must be made to maintain temperature consistency once reconstituted.
Store the product according to the storage recommendations provided on the label or accompanying documentation in your shipment. Proper storage helps maintain product integrity during its shelf life. Most peptides have an expiration date of 2 years if kept unreconstituted (lyophilized powder).
SHIPPING
Shipping times vary based on your location and the shipping method selected at checkout. We offer shipping options between 1 and 5 days.
No.
Once your order is processed, you will receive a shipping confirmation email with tracking information.
ORDERS
Each order includes the peptide vial as described on the product page above.
We accept all forms of credit cards and Zelle.
If your order has not yet been processed for shipment, we may be able to make changes. Please contact customer support as soon as possible after placing your order.
If your order arrives damaged or incorrect, contact our customer support team promptly at support@peaklabpeptides.com with your order number and photos of the package and product so we can assist you.
For the safety of our researchers and integrity of our products we can not accept returns whatsoever.
SUPPORT
If you have questions about your order or a product, please reach out through our customer support page or contact us at support@peaklabpeptides.com or call/text 605-524-2800.
Purity you can verify
TESTED
VERIFICATION
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
AVAILABILITY
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
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Product Details:
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- Purity: >98%
- Form: Lyophilized powder
- Quantity: 10mg or 40mg per vial
- Storage: Store at -4°F (-20°C). After reconstitution, refrigerate at 36–46°F (2–8°C) and use within 30 days.
- Grade: For research purposes only. Not for human consumption or therapeutic applications.
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