DSIP
Price range: $34.20 through $54.40
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99.7% — exceeds 99.00% minimum spec
- Batch
- DS-202607-001
- Test date
- July 23, 2026
- Method
- HPLC + MS
- Lab
-
Bioviridian
College Station, TX
Description
DSIP Peptide (Delta Sleep-Inducing Peptide)
THIS IS NOT FOR HUMAN CONSUMPTION. SOLD FOR RESEARCH ONLY!
Dsip peptide Details
Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide first isolated from the cerebral venous blood of rabbits during induced delta-wave (slow-wave) sleep, and subsequently identified in human cerebrospinal fluid. Despite its name, decades of follow-up research — summarized in review literature as "DSIP: a still unresolved riddle" — have found its relationship to sleep architecture to be more complex than originally proposed, with published studies reporting inconsistent effects on slow-wave sleep induction across species and dosing paradigms. Independent of its sleep-related activity, DSIP has been studied for stress-axis modulation, including effects on ACTH and cortisol regulation, pain-threshold modulation, and circadian rhythm signaling. Its precise receptor target remains unidentified in the literature, and DSIP continues to be studied primarily as a neuromodulatory peptide of interest in stress physiology and sleep-architecture research rather than as a well-characterized single-mechanism compound.
Dsip peptide Scientific Research
1. Neuroendocrine Signaling & Hypothalamic Regulation
DSIP is used in experimental systems to explore regulation of hypothalamic–pituitary signaling. Preclinical studies have observed its modulatory effects on corticotropin and somatostatin secretion, suggesting its role in neuropeptide feedback loops relevant to stress adaptation and hormonal rhythms.
2. Sleep and Circadian Rhythm Studies
DSIP has been employed in rodent models and neuronal cell lines to investigate sleep-promoting activity, phase-shifting properties, and oscillatory peptide expression. It serves as a model compound in sleep-related signal transduction and circadian biochemistry workflows.
3. GABAergic and Monoaminergic Pathway Analysis
Research indicates DSIP may influence GABAergic tone and monoamine oxidase (MAO-A) activity, potentially impacting serotonin and dopamine metabolism. These actions are relevant in research studying emotional regulation, anxiety response, and central neurotransmitter turnover.
4. Stress Adaptation and HPA Axis Dynamics
DSIP is investigated in stress models for its regulatory influence on hypothalamic–pituitary–adrenal (HPA) signaling. It may downregulate ACTH release and affect cortisol dynamics, contributing to studies on neuroendocrine recovery and homeostasis under chronic or acute stress.
5. Mitochondrial Bioenergetics
In cellular bioenergetics research, DSIP is used to assess its impact on mitochondrial respiration, ATP production, and oxidative phosphorylation, particularly under stress or hypoxic conditions in neural tissues.
Article Titles & Journals
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
- Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide
- Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke.
- DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarctio
- Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression
Fast, reliable shipping
We offer fast, reliable shipping through UPS and USPS.
Shipping Options
UPS shipping options include:
- Next Day Air
- 2nd Day Air
- 3 Day Select
- UPS Ground
Order Processing
- We ship Monday through Saturday.
- Orders placed before 6:00 PM EST / 3:00 PM PST are typically shipped the same day.
- Orders placed after the daily cutoff or on holidays will be processed on the next available shipping day.
Puerto Rico, Hawaii & Alaska
- Orders shipping to these destinations are sent via USPS unless alternative arrangements have been made in advance.
- Need a different shipping method? Contact us before placing your order so we can discuss available options.
Order Tracking
- Once your order has shipped, you'll receive a shipping confirmation email with tracking information so you can monitor your delivery.
- Orders totaling $200 or more qualify for FREE UPS 2nd Day Air shipping within the continental United States.
- Free 2nd Day Air shipping does not apply to orders shipping to Puerto Rico, Hawaii, or Alaska.
Handled correctly, stability holds
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
Store vials in a cool, dry place away from heat and direct sunlight.
For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Frequently Asked Questions
PRODUCT & PURITY
This product is offered for laboratory and research use only. It is not intended for human consumption, medical use, therapeutic use, or veterinary use.
Yes, all of our products are sterile and sealed with a sterility plug and safety cap.
Our products undergo quality control internally at our lab and then 3rd party tested at Bioviridian (at their Texas facility) prior to shipment. All of our COA's are then posted on our site immediately upon receipt.
99% or higher. Period. The expected purity is listed on the individual product page or Certificate of Analysis, when available.
No. We are a manufacturing company and because these products are sold for research purposes only, we do not provide dosing, administration, or medical-use guidance.
Unless specifically stated otherwise, these products are not approved by the U.S. Food and Drug Administration for therapeutic or diagnostic use.
STORAGE & STABILITY
As a lyophilized powder, peptides are stable. Delays in shipments up to 7 days will have zero to minimal impact on efficacy of peptides. Most precautionary efforts must be made to maintain temperature consistency once reconstituted.
Store the product according to the storage recommendations provided on the label or accompanying documentation in your shipment. Proper storage helps maintain product integrity during its shelf life. Most peptides have an expiration date of 2 years if kept unreconstituted (lyophilized powder).
SHIPPING
Shipping times vary based on your location and the shipping method selected at checkout. We offer shipping options between 1 and 5 days.
No.
Once your order is processed, you will receive a shipping confirmation email with tracking information.
ORDERS
Each order includes the peptide vial as described on the product page above.
We accept all forms of credit cards and Zelle.
If your order has not yet been processed for shipment, we may be able to make changes. Please contact customer support as soon as possible after placing your order.
If your order arrives damaged or incorrect, contact our customer support team promptly at support@peaklabpeptides.com with your order number and photos of the package and product so we can assist you.
For the safety of our researchers and integrity of our products we can not accept returns whatsoever.
SUPPORT
If you have questions about your order or a product, please reach out through our customer support page or contact us at support@peaklabpeptides.com or call/text 605-524-2800.
Purity you can verify
TESTED
VERIFICATION
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
AVAILABILITY
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
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For laboratory research only. This product is not intended to diagnose, treat, cure, or prevent any disease.
