Melanotan I Nasal Spray
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Description
Melanotan I (MT-1)
THIS IS NOT FOR HUMAN CONSUMPTION. SOLD FOR RESEARCH ONLY!
Melanotan 1 (MT1) is a synthetic linear analog of alpha-melanocyte-stimulating hormone (α-MSH) with the peptide sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂. It is engineered for targeted activation of melanocortin receptors—especially MC1R—making it a valuable research tool for studying pigmentation pathways, GPCR signaling, and transcriptional regulation.
In preclinical settings, Melanotan 1 activates cAMP-dependent second-messenger systems, leading to modulation of genes involved in melanin production and cellular photoprotection. This 10mg lyophilized peptide is strictly intended for laboratory use in receptor pharmacology, melanocyte signaling, and comparative ligand analysis models.
- Peptide Class: α-MSH analog (linear)
- Sequence: Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂
- Primary Targets: MC1R (primary), MC3R, MC4R, MC5R (secondary)
- Mechanism of Action: GPCR agonist; cAMP/PKA signaling cascade activator
- Applications: Pigmentation studies, neuroendocrine research, energy metabolism models
- Format: Lyophilized powder, 10mg per vial
- Purity: ≥99% (HPLC-verified)
- Research Use Only: Not for human or veterinary use
- Melanocortin Receptor Pharmacology
Used in in-vitro cell assays to measure receptor binding and activation across melanocortin receptor subtypes. MT1 supports receptor selectivity comparisons and is frequently paired with signaling reporters like cAMP and PKA-activated transcription factors. - Pigmentation Biology and Melanocyte Models
MT1 is ideal for studying MC1R-mediated melanin production. Research focuses on transcriptional activation of melanogenesis enzymes (e.g., tyrosinase) and analysis of melanosome formation and function in cultured melanocytes. - Neuroendocrine and Neuroimmune Signaling
Research involving CNS tissues or rodent models uses MT1 to examine neurotrophic gene expression, BDNF regulation, and receptor-linked plasticity pathways. MT1 also serves as a tool in inflammation-linked neurobiology research. - Cardiovascular and Autonomic Regulation
In preclinical cardiovascular studies, Melanotan 1 has been used to assess its impact on autonomic balance, blood pressure regulation, and endothelial function via MC receptor signaling. - Energy Metabolism and Metabolic Pathway Probing
Due to MC4R’s role in energy homeostasis, MT1 is used in animal studies to assess receptor-linked regulation of lipid metabolism, substrate oxidation, and body-weight regulation under experimental diets or stressors.
Q: What is Melanotan 1 used for in research?
A: It’s primarily used to study melanocortin receptor activity, pigmentation pathways, neuroendocrine signaling, and energy metabolism in preclinical models.
Q: How is MT1 different from MT2?
A: Melanotan 1 is a linear analog with a higher selectivity toward MC1R, while MT2 is cyclic and binds more broadly to MC1R–MC5R with behavioral and metabolic overlap.
Q: Can MT1 be used for tanning or cosmetic purposes?
A: No. This peptide is strictly intended for laboratory research and is not approved for human use or cosmetic application.
Q: What pathways does MT1 influence?
A: MT1 activates the cAMP/PKA signaling axis, influences transcriptional responses linked to pigmentation, and can modulate neuroimmune and metabolic signaling in receptor-specific models.
Q: What storage conditions are recommended?
A: Store the lyophilized peptide at -20°C. After reconstitution with bacteriostatic water, it should be used promptly or stored under sterile refrigerated conditions and used within a few days.
Storage & Handling
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
- On arrival: Store vials in a cool, dry place away from heat and direct sunlight.
- Long-term (powder): For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
- After reconstitution: Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Note: Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
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