Ara-290 (10mg)
Original price was: $54.00.$44.00Current price is: $44.00.
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99.7% — exceeds 99.00% minimum spec
- Batch
- RA-202607-001
- Test date
- July 23, 2026
- Method
- HPLC + MS
- Lab
-
Bioviridian
College Station, TX
Description
ARA-290 (Cibinetide)
Ara-290 peptide​ Details
ARA-290 (cibinetide) is a synthetic 11-amino-acid peptide engineered from the helix-B region of erythropoietin (EPO), designed specifically to retain EPO's tissue-protective signaling through the innate repair receptor (a heteromer of the EPO receptor and CD131) while eliminating the hematopoietic (red blood cell-stimulating) activity of full-length EPO. This selective design is the compound's central research rationale: because EPO's blood-doping and cardiovascular-risk profile stems from its erythropoiesis-stimulating activity, isolating the tissue-protective helix-B fragment allows researchers to study EPO's neuroprotective and anti-inflammatory signaling in isolation. Published clinical-stage research (conducted under the name cibinetide) has examined ARA-290 in models of neuropathic pain, particularly small-fiber neuropathy, as well as inflammatory and metabolic research contexts, positioning it as a peptide of interest for studying tissue-protective signaling independent of erythropoietic effects.
Ara-290 peptide​ Scientific Research
Blood Vessel and Endothelial Health
Retinal and systemic ischemic injury models have highlighted the importance of endothelial colony forming cells (ECFCs) in vascular repair. ARA-290 has been studied for its ability to:
- Protect ECFCs from inflammation-induced damage
- Enhance ECFC proliferation, migration, and survival
- Improve homing of ECFCs to injured or ischemic regions of the vasculature
These findings support the use of ARA-290 as a probe for mechanisms underlying vascular regeneration and microvascular repair. Research also suggests that ARA-290 may help improve the performance and durability of transplanted ECFCs, a key interest in regenerative medicine and vascular engineering models.
Inflammatory Cytokines and Islet Cell Survival
In models of islet cell transplantation, ARA-290 has been investigated for its potential to modulate inflammatory responses that typically limit graft survival. Studies in mice have shown that:
- ARA-290 can reduce macrophage activation and lessen the secretion of pro-inflammatory cytokines such as IL-6, IL-12, and TNF-α
- Reduced inflammatory signaling correlates with improved survival and function of transplanted islet cells
Mechanistically, these effects are linked to ARA-290 binding to tissue-protective receptor complexes, leading to decreased apoptosis, enhanced tissue protection, and more favorable local immune profiles. These results are experimental and focused on understanding how selective immune modulation can improve cell transplant outcomes.
Tissue Protection and Repair
ARA-290’s tissue-protective activity has been demonstrated across multiple preclinical models of injury and inflammation. Engagement of the TPR/IRR is associated with:
- Reduced apoptotic cell death in stressed tissues
- Diminished levels of damaging inflammatory cytokines
- Enhanced tissue regeneration, faster wound closure, and reduced scar formation in experimental wound models
These properties have led to significant interest in ARA-290 as a tool compound to study the biology of injury response, wound repair, and organ protection under ischemic or inflammatory conditions, particularly in the context of metabolic diseases such as diabetes.
Immune System Modulation
The TPR is expressed on several immune cell types, including macrophages, dendritic cells, mast cells, and T cells. ARA-290 has been used to interrogate how selective receptor targeting can reshape immune responses:
- In macrophages, ARA-290 reduces secretion of TNF-α and IL-6, which can limit excessive inflammation while still permitting pathogen control in many settings.
- ARA-290 influences chemokine signaling, reducing recruitment of inflammatory cells while supporting the activity of resident tissue macrophages involved in repair.
- Studies suggest that ARA-290 can modulate antigen presentation by dendritic cells, potentially altering adaptive immune responses and graft rejection pathways.
These immune-modulating properties have prompted investigations of ARA-290 in experimental models of colitis, systemic lupus erythematosus (SLE), and other autoimmune or inflammatory conditions. In certain lupus models, ARA-290 has been associated with reduced autoantibody levels and improved kidney parameters, illustrating its utility in studying targeted immune modulation.
Neuropathic Pain and Small Fiber Neuropathy
One of the most advanced areas of ARA-290 research relates to neuropathic pain and small fiber neuropathy:
- ARA-290 acts on the innate repair receptor, and emerging data indicate that it can also inhibit TRPV1 channel activity (the capsaicin/heat receptor), a key mediator of burning and heat-related pain.
- Studies in subjects with small fiber neuropathy (e.g., associated with sarcoidosis or metabolic disease) have reported increases in intraepidermal nerve fiber density and reductions in pain scores following ARA-290 exposure in controlled settings.
- These effects have led to clinical development of ARA-290 (also known as cibinetide) in neuropathic pain indications, including sarcoid neuropathy and diabetic neuropathy, under regulated investigational protocols.
In research contexts, ARA-290 therefore serves as a powerful tool to explore the relationship between immune signaling, nerve fiber integrity, and chronic neuropathic pain mechanisms.
Orphan and Translational Development Context
ARA-290 (cibinetide) has received orphan drug designation in specific neuropathic conditions and has progressed into mid- and late-stage clinical trials in those settings. From a research perspective, this makes ARA-290 particularly relevant in:
- Translational neuropathy models
- Chronic inflammatory and autoimmune pain syndromes
- Diabetic wound-healing and impaired tissue repair models
While these developments highlight its translational potential, ARA-290 supplied as a research peptide remains intended solely for non-clinical experimental use.
Article Titles & Journals
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Handled correctly, stability holds
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
Store vials in a cool, dry place away from heat and direct sunlight.
For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Frequently Asked Questions
PRODUCT & PURITY
This product is offered for laboratory and research use only. It is not intended for human consumption, medical use, therapeutic use, or veterinary use.
Yes, all of our products are sterile and sealed with a sterility plug and safety cap.
Our products undergo quality control internally at our lab and then 3rd party tested at Bioviridian (at their Texas facility) prior to shipment. All of our COA's are then posted on our site immediately upon receipt.
99% or higher. Period. The expected purity is listed on the individual product page or Certificate of Analysis, when available.
No. We are a manufacturing company and because these products are sold for research purposes only, we do not provide dosing, administration, or medical-use guidance.
Unless specifically stated otherwise, these products are not approved by the U.S. Food and Drug Administration for therapeutic or diagnostic use.
STORAGE & STABILITY
As a lyophilized powder, peptides are stable. Delays in shipments up to 7 days will have zero to minimal impact on efficacy of peptides. Most precautionary efforts must be made to maintain temperature consistency once reconstituted.
Store the product according to the storage recommendations provided on the label or accompanying documentation in your shipment. Proper storage helps maintain product integrity during its shelf life. Most peptides have an expiration date of 2 years if kept unreconstituted (lyophilized powder).
SHIPPING
Shipping times vary based on your location and the shipping method selected at checkout. We offer shipping options between 1 and 5 days.
No.
Once your order is processed, you will receive a shipping confirmation email with tracking information.
ORDERS
Each order includes the peptide vial as described on the product page above.
We accept all forms of credit cards and Zelle.
If your order has not yet been processed for shipment, we may be able to make changes. Please contact customer support as soon as possible after placing your order.
If your order arrives damaged or incorrect, contact our customer support team promptly at support@peaklabpeptides.com with your order number and photos of the package and product so we can assist you.
For the safety of our researchers and integrity of our products we can not accept returns whatsoever.
SUPPORT
If you have questions about your order or a product, please reach out through our customer support page or contact us at support@peaklabpeptides.com or call/text 605-524-2800.
Purity you can verify
TESTED
VERIFICATION
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
AVAILABILITY
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
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