TB-500
Price range: $38.00 through $54.00
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99.8% — exceeds 99.00% minimum spec
- Batch
- TB-202604-001
- Test date
- April 30, 2026
- Method
- HPLC + MS
- Lab
-
Bioviridian
College Station, TX
Description
TB-500 (TB500)
TB-500 peptide Details
TB-500 is a synthetic fragment of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide present in nearly all human and animal cells and found in high concentrations in platelets and wound fluid. Research on Tβ4 and its active fragment centers on actin-binding activity — the peptide binds G-actin, influencing cell migration, cytoskeletal remodeling, and angiogenesis. This has made TB-500 a frequent subject of tissue-repair and wound-healing research, where it is studied for its role in promoting cell migration to injury sites, supporting new blood vessel formation, and modulating inflammatory cytokines during the repair cascade. Preclinical studies have examined its involvement in tendon, ligament, muscle, and corneal repair models, as well as cardiac tissue recovery following ischemic injury. TB-500 is widely referenced in combination with BPC-157 (the "Wolverine Stack") in research exploring synergistic tissue-repair pathways, given that the two peptides act on complementary mechanisms — actin regulation (TB-500) and growth-factor/angiogenic signaling (BPC-157).
TB-500 peptide Scientific Research
1. Cytoskeletal Remodeling
TB-500 regulates the actin cytoskeleton by sequestering G-actin and promoting polymerization into F-actin. This process is essential for changes in cell shape, migration, and structural plasticity.
2. Angiogenesis & Endothelial Cell Function
TB-500 has demonstrated pro-angiogenic properties in vitro and in vivo. It upregulates vascular endothelial growth factor (VEGF) and supports endothelial cell migration and tube formation, which are crucial for neovascularization in tissue repair models.
3. Wound Healing & Epithelial Regeneration
Studies have observed accelerated epithelialization in dermal and corneal injury models, suggesting that TB-500 promotes cell migration and tissue reorganization in healing wounds.
4. Anti-Inflammatory and Oxidative Stress Modulation
TB-500 influences inflammation resolution and cellular responses to oxidative stress, likely via modulation of key transcriptional regulators and cytokine pathways. It’s used in studies investigating systemic and localized tissue stress.
5. Extracellular Matrix & Tissue Remodeling
The peptide plays a role in ECM remodeling by influencing fibroblast activation, collagen deposition, and MMP (matrix metalloproteinase) expression, which are all key elements in soft tissue regeneration.
Article Titles & Journals
- Dysregulation of circulating damage-associated molecular patterns in diabetic foot syndrom
- Understanding the effects of ciprofloxacin on corneal epithelial cells: a study using elec
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injur
- Engineered Tandem Thymosin Peptide Promotes Corneal Wound Healing.
Fast, reliable shipping
We offer fast, reliable shipping through UPS and USPS.
Shipping Options
UPS shipping options include:
- Next Day Air
- 2nd Day Air
- 3 Day Select
- UPS Ground
Order Processing
- We ship Monday through Saturday.
- Orders placed before 6:00 PM EST / 3:00 PM PST are typically shipped the same day.
- Orders placed after the daily cutoff or on holidays will be processed on the next available shipping day.
Puerto Rico, Hawaii & Alaska
- Orders shipping to these destinations are sent via USPS unless alternative arrangements have been made in advance.
- Need a different shipping method? Contact us before placing your order so we can discuss available options.
Order Tracking
- Once your order has shipped, you'll receive a shipping confirmation email with tracking information so you can monitor your delivery.
- Orders totaling $200 or more qualify for FREE UPS 2nd Day Air shipping within the continental United States.
- Free 2nd Day Air shipping does not apply to orders shipping to Puerto Rico, Hawaii, or Alaska.
Handled correctly, stability holds
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
Store vials in a cool, dry place away from heat and direct sunlight.
For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Frequently Asked Questions
PRODUCT & PURITY
This product is offered for laboratory and research use only. It is not intended for human consumption, medical use, therapeutic use, or veterinary use.
Yes, all of our products are sterile and sealed with a sterility plug and safety cap.
Our products undergo quality control internally at our lab and then 3rd party tested at Bioviridian (at their Texas facility) prior to shipment. All of our COA's are then posted on our site immediately upon receipt.
99% or higher. Period. The expected purity is listed on the individual product page or Certificate of Analysis, when available.
No. We are a manufacturing company and because these products are sold for research purposes only, we do not provide dosing, administration, or medical-use guidance.
Unless specifically stated otherwise, these products are not approved by the U.S. Food and Drug Administration for therapeutic or diagnostic use.
STORAGE & STABILITY
As a lyophilized powder, peptides are stable. Delays in shipments up to 7 days will have zero to minimal impact on efficacy of peptides. Most precautionary efforts must be made to maintain temperature consistency once reconstituted.
Store the product according to the storage recommendations provided on the label or accompanying documentation in your shipment. Proper storage helps maintain product integrity during its shelf life. Most peptides have an expiration date of 2 years if kept unreconstituted (lyophilized powder).
SHIPPING
Shipping times vary based on your location and the shipping method selected at checkout. We offer shipping options between 1 and 5 days.
No.
Once your order is processed, you will receive a shipping confirmation email with tracking information.
ORDERS
Each order includes the peptide vial as described on the product page above.
We accept all forms of credit cards and Zelle.
If your order has not yet been processed for shipment, we may be able to make changes. Please contact customer support as soon as possible after placing your order.
If your order arrives damaged or incorrect, contact our customer support team promptly at support@peaklabpeptides.com with your order number and photos of the package and product so we can assist you.
For the safety of our researchers and integrity of our products we can not accept returns whatsoever.
SUPPORT
If you have questions about your order or a product, please reach out through our customer support page or contact us at support@peaklabpeptides.com or call/text 605-524-2800.
Purity you can verify
TESTED
VERIFICATION
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
AVAILABILITY
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
