TB-500
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Description
TB-500 (TB500)
TB-500 peptide Details
TB-500 Certificate of Analysis
Third-party tested. Click image to view full-resolution certificate.
TB-500 (Thymosin Beta-4) is a synthetic research peptide that mirrors a 43-amino-acid sequence of the naturally occurring actin-sequestering protein found in many tissues. It plays a significant role in cellular motility, tissue repair, and regeneration by modulating the polymerization and organization of actin filaments.
In preclinical models, TB-500 has been studied for its ability to influence cell migration, angiogenesis, and inflammatory responses. By regulating the G-actin/F-actin balance and promoting the expression of critical growth factors, TB-500 is a key tool in regenerative peptide research.
About TB-500 peptide
- Alias: Thymosin Beta-4 (Tβ4)
- Sequence: SDKP… (43 amino acids)
- Molecular Formula: C212H350N56O78S
- Molecular Weight: ~4963.5 Da
- Purity: ≥98% (HPLC verified)
- Form: Lyophilized peptide
- For Research Use Only: Not for human or veterinary use
7 reviews for TB-500
TB-500 peptide Scientific Research
1. Cytoskeletal Remodeling
TB-500 regulates the actin cytoskeleton by sequestering G-actin and promoting polymerization into F-actin. This process is essential for changes in cell shape, migration, and structural plasticity.
2. Angiogenesis & Endothelial Cell Function
TB-500 has demonstrated pro-angiogenic properties in vitro and in vivo. It upregulates vascular endothelial growth factor (VEGF) and supports endothelial cell migration and tube formation, which are crucial for neovascularization in tissue repair models.
3. Wound Healing & Epithelial Regeneration
Studies have observed accelerated epithelialization in dermal and corneal injury models, suggesting that TB-500 promotes cell migration and tissue reorganization in healing wounds.
4. Anti-Inflammatory and Oxidative Stress Modulation
TB-500 influences inflammation resolution and cellular responses to oxidative stress, likely via modulation of key transcriptional regulators and cytokine pathways. It’s used in studies investigating systemic and localized tissue stress.
5. Extracellular Matrix & Tissue Remodeling
The peptide plays a role in ECM remodeling by influencing fibroblast activation, collagen deposition, and MMP (matrix metalloproteinase) expression, which are all key elements in soft tissue regeneration.
TB-500 peptide FAQ
Q: What is TB-500 derived from?
A: TB-500 is a synthetic peptide modeled after the natural protein Thymosin Beta-4, found in various mammalian tissues.
Q: What is the primary function of TB-500 in research?
A: It is used to study cellular migration, angiogenesis, and wound healing through actin cytoskeleton regulation.
Q: Is TB-500 injectable?
A: While some experimental studies use injection as a delivery method in animal models, TB-500 is strictly for research purposes and not for human administration.
Q: Can TB-500 promote muscle or tendon repair?
A: In preclinical studies, TB-500 has shown potential for improving soft tissue recovery in musculoskeletal models.
Q: Does TB-500 affect inflammation?
A: Yes. It has been studied for its anti-inflammatory and oxidative stress modulating properties, making it useful in systemic recovery models.
Storage & Handling
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
- On arrival: Store vials in a cool, dry place away from heat and direct sunlight.
- Long-term (powder): For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
- After reconstitution: Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Note: Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
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KLOW Blend 80mg – GHK-Cu, TB-500, BPC-157, KPV
KLOW – 80mg Peptide Blend (Lyophilized Powder) – For Research Use Only GHK-Cu • TB-500 • BPC-157 • KPV
KLOW is an advanced 4-in-1 research peptide blend combining 80mg of regenerative and anti-inflammatory compounds studied for their potential in tissue repair, immune modulation, and cellular recovery. Designed for comprehensive healing models, KLOW offers synergistic support across skin, muscle, and gut research applications. Active Ingredients (Per Vial): GHK-Cu – 50mg Studied for skin regeneration, wound healing, collagen stimulation, and hair follicle support. TB-500 – 10mg A fragment of Thymosin Beta-4, known for supporting angiogenesis, cell migration, and muscle recovery. BPC-157 – 10mg Derived from a gastric protein, BPC-157 is studied for gut repair, tendon/ligament healing, and anti-inflammatory effects. KPV – 10mg A tripeptide fragment with strong research interest for localized inflammation and immune modulation, particularly in the gut and skin. Product Details: Total Peptide Content: 80mg per vial: Lyophilized powder Purity: >98% Storage: Store at -4°F (-20°C). After reconstitution, refrigerate at 36–46°F (2–8°C) and use within 30 days. Grade: For research purposes only. Not for human consumption, therapeutic, or diagnostic use. Potential Research Applications: Soft tissue, muscle, and ligament repair Skin rejuvenation and wound healing models Inflammatory bowel and gut barrier integrity studies Anti-inflammatory and immune modulation research For laboratory research only. This product is not intended to diagnose, treat, cure, or prevent any disease.
Peptide Storage Case (3ml x 5 + Multi-Compartment) — Hard Shell Complete Organizer
An all-in-one solution for organizing your full research workflow.
This hard shell peptide storage case is designed to securely hold up to 5 standard 3ml vials, with additional dedicated compartments for other essential research materials. The precision-fit interior keeps every component stable and separated, so your full setup stays organized in a single case.
Built with a lightweight, impact-resistant shell and secure snap latches, this case is freezer and refrigerator safe — making it a reliable option for both at-home storage and on-the-go use.
Key Features:
- Custom-fit layout: Holds 5 × 3ml vials plus dedicated storage for essential research supplies
- Hard shell exterior: Durable, impact-resistant protection
- Secure snap latches: Keeps contents safely contained
- Precision interior compartments: Minimize movement and vibration
- Freezer & refrigerator safe: Maintains integrity in cold storage
- Compact dimensions: 6.75"W × 4"D × 2.25"H
- Travel-friendly: Lightweight and easy to transport
The most complete option in our storage lineup, built for researchers who want everything organized in one place.
Important:
- For research use only. Not for human consumption.
- Vials and supplies not included
Peptide Storage Case (3ml x 8, 10ml x 1) — Hard Shell Protective Organizer
Keep your research materials organized, protected, and ready for use.
This hard shell peptide storage case is designed to securely hold up to 8 standard 3ml vials and 1 larger 10ml vial, with a precision-fit interior that keeps everything in place during transport or storage.
The compact, durable design makes it ideal for both at-home organization and on-the-go use, while the structured interior prevents movement, tipping, or contact between vials.
Key Features:
- Custom-fit layout: Holds 8 × 3ml vials + 1 × 10ml vial
- Hard shell exterior: Durable, impact-resistant protection
- Secure closure: Keeps contents safely contained
- Precision interior insert: Minimizes movement and vibration
- Compact & travel-friendly: Easy to store or carry
Built for reliability and clean organization, this case helps maintain a professional and efficient research setup.
Important:
- For research use only. Not for human consumption.
- Vials not included
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A dependable source for research-grade peptides.
Ricky –
“Interesting article on TB-500’s potential applications in tissue repair and inflammation control! Given its mechanism involving actin binding and angiogenesis, I’m curious if anyone has explored synergistic effects when combining it with other peptides like BPC-157 or KPV? I recently came across a detailed discussion on this topic here: https://mindbodyneurology.com/bpc-157-and-kpv_peptides-for-mcas/. Has anyone in the research community tested such combinations in controlled models?”
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