MT-2 (Melanotan 2) – 10mg Nasal Spray
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Description
Melanotan II (MT-2)
THIS IS NOT FOR HUMAN CONSUMPTION. SOLD FOR RESEARCH ONLY!
Melanotan II (MT-2) Certificate of Analysis
Third-party tested. Click image to view full-resolution certificate.
Melanotan 2 (MT-2) is a synthetic cyclic heptapeptide (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂) structurally related to alpha-melanocyte-stimulating hormone (α-MSH). It acts as a potent, nonselective agonist across multiple melanocortin receptor subtypes (MC1R–MC5R). MT2 is widely used in receptor biology studies focusing on signal transduction, cAMP-mediated activation, and GPCR desensitization processes.
This 10mg lyophilized vial is intended for laboratory use in examining neuroendocrine signaling, pigmentation-related gene expression, and behavioral peptide pharmacology under well-controlled experimental frameworks.
- Peptide Type: Synthetic cyclic heptapeptide
- Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
- Receptor Targets: MC1R, MC3R, MC4R, MC5R (nonselective agonist)
- Mechanism: GPCR activation, intracellular cAMP signaling, and receptor desensitization
- Research Use Only: Not for human consumption or therapeutic use
- Purity: ≥99% (HPLC-verified)
- Melanocortin Receptor Pharmacology
MT2 is widely used in receptor-binding assays to evaluate subtype specificity, binding affinity, and functional efficacy across melanocortin receptors. It serves as a tool to assess receptor activation thresholds and desensitization mechanisms in in-vitro cell lines. - Second-Messenger Signaling Analysis
Commonly used in signal transduction studies measuring cAMP accumulation and downstream effector activation (e.g., ERK/MAPK), Melanotan 2 provides a robust model for quantifying GPCR-mediated transcriptional cascades. - Pigmentation Pathways & Melanocyte Signaling
In melanocyte and pigmentation biology, MT2 is used to explore melanogenesis-related gene expression and the influence of MC1R signaling on melanin synthesis. It assists in mapping photoprotection pathways and UV-response models in dermatological research. - Behavioral Neuroscience Models
Experimental studies with rodent models often use MT2 to investigate neurobehavioral responses such as feeding behavior, sexual arousal pathways, reward processing, and motivational circuitry, all linked to MC3R and MC4R signaling. - Systems Biology & Tissue Mapping
Melanotan 2 is applied in systems-level studies to evaluate receptor expression across tissues and to trace peptide-linked signaling networks using transcriptional and proteomic approaches in organ-specific models.
Q: What is Melanotan 2 used for in research?
A: MT2 is primarily used to study melanocortin receptor activation, GPCR signaling, neuroendocrine responses, pigmentation mechanisms, and behavioral pathways in preclinical models.
Q: Which receptors does MT2 activate?
A: It is a nonselective agonist that activates MC1R through MC5R, with high affinity for MC1R (pigmentation) and MC4R (neurobehavior).
Q: Is Melanotan 2 intended for human use or tanning?
A: No. This product is for scientific research only and is not intended for tanning or clinical use under any circumstances.
Q: What signaling pathways does it influence?
A: It primarily activates the cAMP–PKA pathway and can also influence MAPK/ERK cascades depending on cell type and receptor subtype.
Q: How is Melanotan 2 stored for research?
A: MT2 should be stored lyophilized at -20°C or below and reconstituted with bacteriostatic water immediately prior to experimental use. Avoid repeated freeze-thaw cycles.
Storage & Handling
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
- On arrival: Store vials in a cool, dry place away from heat and direct sunlight.
- Long-term (powder): For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
- After reconstitution: Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Note: Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
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