MOTS-c Nasal Spray

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Purity 99.8% Batch MS-202607-001 Tested Jul 23, 2026 Full report ↓
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Description

MOTS-c

MOTS-c – 10mg (Lyophilized Peptide) – For Research Use Only

MOTS-c is a mitochondrial-derived peptide (MDP) encoded by the mitochondrial genome, widely studied for its potential role in metabolic regulation, energy homeostasis, and cellular protection. Research has focused on its ability to influence glucose metabolism, insulin sensitivity, and mitochondrial function, making it a key subject in studies on metabolic health and aging.

MOTS-c is of special interest in research exploring exercise mimetic effects, fat metabolism, and metabolic syndrome models.

Product Details:

  • Peptide: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)

  • Purity: >98%

  • Form: Lyophilized powder

  • Quantity: 10mg per vial

  • Storage: Store at -4°F (-20°C). After reconstitution, refrigerate at 36–46°F (2–8°C) and use within 30 days.

  • Grade: For research purposes only. Not for human consumption or therapeutic applications.

Potential Research Applications:

  • Glucose metabolism and insulin sensitivity studies

  • Mitochondrial function and energy regulation research

  • Aging, longevity, and metabolic health models

  • Exercise mimetic and fat metabolism investigations


For laboratory research use only. This product is not intended to diagnose, treat, cure, or prevent any disease.

THIS IS NOT FOR HUMAN CONSUMPTION. SOLD FOR RESEARCH ONLY!

Current batch Passed
Purity 99.8%

99.8% — exceeds 99.00% minimum spec

Batch
MS-202607-001
Test date
July 23, 2026
Method
HPLC + MS
Lab
Bioviridian
College Station, TX
Description + COA

MOTS-c Nasal Spray peptide Details

MOTS-c Nasal Spray — Research Grade | Pre-Formulated Liquid Solution

This nasal spray formulation delivers MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) as a pre-formulated, sterile liquid solution for research use. No reconstitution is required — the product arrives ready for laboratory application via the nasal spray delivery format.

MOTS-c is a 16-amino acid peptide encoded within the mitochondrial genome — specifically in the 12S rRNA region. It functions as a mitochondrial-derived peptide (MDP) with roles in metabolic regulation, insulin sensitivity, exercise response, and aging research. Studies have identified it as a potential mitokine capable of translocating to the nucleus and regulating gene expression.

Nasal spray format note: This product is supplied as a metered-dose nasal spray bottle for research convenience. Transmucosal delivery of mitochondrial-derived peptides is an emerging area of preclinical investigation. All use is strictly for laboratory and research purposes only.

⚠️ For Research Use Only — Not for human consumption. Requires 2nd Day Air or Next Day Air shipping (no ground shipping available).

Research

MOTS-c Nasal Spray peptide Scientific Research

1. AMPK Activation & Metabolic Regulation

MOTS-c has been shown in preclinical studies to activate AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. AMPK activation helps promote glucose uptake, lipid oxidation, and improved mitochondrial efficiency in both in-vitro and in-vivo models.

2. Mitochondrial–Nuclear Signaling

MOTS-c is reported to translocate from mitochondria to the nucleus under stress conditions, influencing nuclear gene expression linked to metabolic regulation. This mitochondrial-nuclear crosstalk is a growing area of research in aging biology and cellular adaptation.

3. Stress Resistance & Longevity Pathways

Studies suggest MOTS-c enhances cellular resistance to metabolic stress by regulating redox balance, promoting mitochondrial biogenesis, and modulating stress-adaptive genes. It has been explored in models evaluating lifespan, exercise performance, and oxidative stress responses.

4. Obesity & Insulin Sensitivity Models

Preclinical studies have used MOTS-c in obesity and glucose metabolism models to examine its potential in modulating insulin sensitivity, weight regulation, and lipid metabolism. Results highlight its relevance in diabetes and metabolic disease frameworks.

5. Molecular Biomarker Profiling

Researchers use MOTS-c to analyze gene expression changes in metabolic pathways, focusing on AMPK targets, sirtuins, inflammatory cytokines, and mitochondrial dynamics proteins (e.g., PGC-1α, NRF1, TFAM) across tissues such as liver, muscle, and adipose.

 

Article Titles & Journals

Shipping

Nasal Spray Products

Nasal spray products are liquid formulations and require expedited shipping to maintain product integrity.

⚠️ IMPORTANT
  • Ground shipping is NOT available for nasal spray orders.
  • We offer fast, reliable shipping through UPS.

Shipping Options (Nasal Spray Only)

UPS shipping options for nasal spray products:

  • Next Day Air
  • 2nd Day Air
  • ❌ 3 Day Select — Not available
  • ❌ UPS Ground — Not available

Why Expedited Shipping Only?

  • Nasal spray products are pre-formulated liquid solutions, unlike lyophilized (powder) peptides.
  • Liquid formulations are more sensitive to temperature changes and extended transit times.
  • Expedited shipping ensures cold-chain integrity and product stability upon delivery.

Order Processing

  • We ship Monday through Saturday.
  • Orders placed before 6:00 PM EST / 3:00 PM PST are typically shipped the same day.
  • Orders placed after the daily cutoff or on holidays will be processed on the next available shipping day.

Puerto Rico, Hawaii & Alaska

  • Please contact us before placing your order to discuss available expedited shipping options for these destinations.

Order Tracking

  • Once your order has shipped, you'll receive a shipping confirmation email with tracking information so you can monitor your delivery.
FREE 2ND DAY AIR SHIPPING
  • Orders totaling $200 or more qualify for FREE UPS 2nd Day Air shipping within the continental United States.
  • Free 2nd Day Air shipping does not apply to orders shipping to Puerto Rico, Hawaii, or Alaska.
Storage & handling

Handled correctly, stability holds

All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.

01 — ON ARRIVAL

Store vials in a cool, dry place away from heat and direct sunlight.

02 — LONG-TERM (POWDER)

For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.

03 — AFTER RECONSTITUTION

Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.

NOTE

Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.

FAQ

Frequently Asked Questions

PRODUCT & PURITY

This product is offered for laboratory and research use only. It is not intended for human consumption, medical use, therapeutic use, or veterinary use.

Yes, all of our products are sterile and sealed with a sterility plug and safety cap.

Our products undergo quality control internally at our lab and then 3rd party tested at Bioviridian (at their Texas facility) prior to shipment. All of our COA's are then posted on our site immediately upon receipt.

99% or higher. Period. The expected purity is listed on the individual product page or Certificate of Analysis, when available.

No. We are a manufacturing company and because these products are sold for research purposes only, we do not provide dosing, administration, or medical-use guidance.

Unless specifically stated otherwise, these products are not approved by the U.S. Food and Drug Administration for therapeutic or diagnostic use.

STORAGE & STABILITY

As a lyophilized powder, peptides are stable. Delays in shipments up to 7 days will have zero to minimal impact on efficacy of peptides. Most precautionary efforts must be made to maintain temperature consistency once reconstituted.

Store the product according to the storage recommendations provided on the label or accompanying documentation in your shipment. Proper storage helps maintain product integrity during its shelf life. Most peptides have an expiration date of 2 years if kept unreconstituted (lyophilized powder).

SHIPPING

Shipping times vary based on your location and the shipping method selected at checkout. We offer shipping options between 1 and 5 days.

No.

Once your order is processed, you will receive a shipping confirmation email with tracking information.

ORDERS

Each order includes the peptide vial as described on the product page above.

We accept all forms of credit cards and Zelle.

If your order has not yet been processed for shipment, we may be able to make changes. Please contact customer support as soon as possible after placing your order.

If your order arrives damaged or incorrect, contact our customer support team promptly at support@peaklabpeptides.com with your order number and photos of the package and product so we can assist you.

For the safety of our researchers and integrity of our products we can not accept returns whatsoever.

SUPPORT

If you have questions about your order or a product, please reach out through our customer support page or contact us at support@peaklabpeptides.com or call/text 605-524-2800.

QUALITY & TESTING

Purity you can verify

3RD-PARTY
TESTED

VERIFICATION

Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.

AVAILABILITY

We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.

INTENDED USE

All products are for laboratory research use only and are not intended for human consumption.