Become a Member and save 20% on Every Order.
99.8% — exceeds 99.00% minimum spec
- Batch
- TB-202604-001
- Test date
- April 30, 2026
- Method
- HPLC + MS
- Lab
-
Bioviridian
College Station, TX
Description
TB-500 (Thymosin Beta-4 Fragment) 10 Vial Kit
TB-500 – 5mg (Lyophilized Peptide) 10 Vial Kit – For Research Use Only
TB-500 is a synthetic peptide corresponding to a 43-amino acid sequence of Thymosin Beta-4 (Tβ4), an actin-binding protein naturally distributed across mammalian tissues. It is one of the most widely studied regenerative research peptides in preclinical science, with a substantial body of literature examining its roles in cell migration, angiogenesis, cytoskeletal dynamics, and tissue repair signaling.
Chemical Profile
- Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
- Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
- Molecular Weight: 4,963 Da
- CAS Number: 77591-33-4
- Form: Lyophilized powder
- Purity: >99% (HPLC verified)
- Quantity: 5mg per vial / 10 vials per kit
- Storage: Store at -20°C long term / 4°C after reconstitution
TB-500 in Preclinical Research
Actin Binding and Cytoskeletal Dynamics TB-500’s primary mechanism of interest involves its interaction with G-actin (globular actin), the monomeric form of actin that regulates filament assembly. By sequestering G-actin, TB-500 influences the G-actin/F-actin balance, which in turn affects cellular processes dependent on cytoskeletal remodeling including cell migration, membrane dynamics, and cytokinesis.
Cell Migration Research One of the most studied properties of TB-500 in preclinical systems is its role in promoting cell migration. Research has examined how TB-500’s actin-modulating activity influences the motility of endothelial cells, keratinocytes, and fibroblasts — cell types central to tissue regeneration processes.
Angiogenesis Research TB-500 has been studied in the context of angiogenesis, the formation of new blood vessels from pre-existing vasculature. Preclinical models suggest it may influence VEGF-related transcriptional programs and endothelial cell behavior relevant to vascular repair and tissue perfusion research.
Tissue Repair and Wound Healing Models Multiple preclinical studies have examined TB-500 in wound healing models, investigating its effects on repair timelines, cellular recruitment, and extracellular matrix dynamics. A 2024 study identified TB-500 metabolites — particularly Ac-LKKTE — as potentially contributing to observed wound healing activity in vitro.
Inflammatory Signaling Research Preclinical research has investigated TB-500 in the context of inflammatory pathway modulation, examining its interactions with oxidative stress signaling and innate pathway nodes under experimentally defined stress conditions.
Cardiac and Vascular Research Emerging preclinical literature has studied TB-500 in cardiac tissue models, examining its potential interactions with cardiomyocyte survival signaling and vascular integrity mechanisms following experimental injury.
TB-500 vs BPC-157: Research Distinctions
TB-500 and BPC-157 are frequently studied together due to their complementary preclinical research profiles, but they have distinct molecular mechanisms:
| TB-500 | BPC-157 | |
|---|---|---|
| Type | Thymosin Beta-4 fragment | Gastric pentadecapeptide |
| Size | 43 amino acids | 15 amino acids |
| Primary Mechanism | Actin binding / G-actin sequestration | NO system / VEGF modulation |
| Key Research Area | Cell migration, cytoskeletal dynamics | Tissue repair, GI mucosal research |
Both are available individually or as the Wolverine Research Combo — BPC-157 and TB-500 bundled together for researchers studying complementary repair pathways.
Quality and Testing Standards
- HPLC Analysis — Confirms >99% purity
- Mass Spectrometry — Confirms correct peptide sequence and molecular identity
- Batch-Specific COA — Certificate of Analysis included with every order
- Third-Party Verified — Independent laboratory testing on every production run
Frequently Asked Questions
What is TB-500? TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4, an actin-binding protein studied for its roles in cell migration, angiogenesis, and tissue repair mechanisms in preclinical models.
What purity is Peak Lab Peptides TB-500? Our TB-500 is HPLC verified to >99% purity with mass spectrometry identity confirmation. Every batch includes a third-party Certificate of Analysis.
Is TB-500 the same as Thymosin Beta-4? TB-500 corresponds to a specific 43-amino acid sequence of Thymosin Beta-4 (Tβ4). It is a synthetic analog used in research to study the biological activity associated with the Tβ4 actin-binding domain.
How should TB-500 be stored? Store lyophilized TB-500 at -20°C for long-term stability. After reconstitution with bacteriostatic water, store at 4°C and use within 28 days.
What is the difference between TB-500 and BPC-157? TB-500 is primarily studied for actin-binding dynamics and cell migration mechanisms. BPC-157 is primarily studied for NO system modulation and VEGF signaling. Both are available as the Wolverine Research Combo for researchers studying complementary pathways.
For laboratory research use only. Not for human or veterinary use, consumption, or medical application.
TB-500 10 vial kit peptide Details
TB-500 is a synthetic fragment of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide present in nearly all human and animal cells and found in high concentrations in platelets and wound fluid. Research on Tβ4 and its active fragment centers on actin-binding activity — the peptide binds G-actin, influencing cell migration, cytoskeletal remodeling, and angiogenesis. This has made TB-500 a frequent subject of tissue-repair and wound-healing research, where it is studied for its role in promoting cell migration to injury sites, supporting new blood vessel formation, and modulating inflammatory cytokines during the repair cascade. Preclinical studies have examined its involvement in tendon, ligament, muscle, and corneal repair models, as well as cardiac tissue recovery following ischemic injury. TB-500 is widely referenced in combination with BPC-157 (the "Wolverine Stack") in research exploring synergistic tissue-repair pathways, given that the two peptides act on complementary mechanisms — actin regulation (TB-500) and growth-factor/angiogenic signaling (BPC-157).
TB-500 10 vial kit peptide Scientific Research
1. Cytoskeletal Remodeling
TB-500 10 vial kit regulates the actin cytoskeleton by sequestering G-actin and promoting polymerization into F-actin. This process is essential for changes in cell shape, migration, and structural plasticity.
2. Angiogenesis & Endothelial Cell Function
TB-500 10 vial kit has demonstrated pro-angiogenic properties in vitro and in vivo. It upregulates vascular endothelial growth factor (VEGF) and supports endothelial cell migration and tube formation, which are crucial for neovascularization in tissue repair models.
3. Wound Healing & Epithelial Regeneration
Studies have observed accelerated epithelialization in dermal and corneal injury models, suggesting that TB-500 10 vial kit promotes cell migration and tissue reorganization in healing wounds.
4. Anti-Inflammatory and Oxidative Stress Modulation
TB-500 10 vial kit influences inflammation resolution and cellular responses to oxidative stress, likely via modulation of key transcriptional regulators and cytokine pathways. It’s used in studies investigating systemic and localized tissue stress.
5. Extracellular Matrix & Tissue Remodeling
The peptide plays a role in ECM remodeling by influencing fibroblast activation, collagen deposition, and MMP (matrix metalloproteinase) expression, which are all key elements in soft tissue regeneration.
Article Titles & Journals
- Dysregulation of circulating damage-associated molecular patterns in diabetic foot syndrom
- Understanding the effects of ciprofloxacin on corneal epithelial cells: a study using elec
- Peptide Therapies in Thyroid Health: Emerging Applications in Endocrine and Immune Modulat
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injur
- Engineered Tandem Thymosin Peptide Promotes Corneal Wound Healing.
Fast, reliable shipping
We offer fast, reliable shipping through UPS and USPS.
Shipping Options
UPS shipping options include:
- Next Day Air
- 2nd Day Air
- 3 Day Select
- UPS Ground
Order Processing
- We ship Monday through Saturday.
- Orders placed before 6:00 PM EST / 3:00 PM PST are typically shipped the same day.
- Orders placed after the daily cutoff or on holidays will be processed on the next available shipping day.
Puerto Rico, Hawaii & Alaska
- Orders shipping to these destinations are sent via USPS unless alternative arrangements have been made in advance.
- Need a different shipping method? Contact us before placing your order so we can discuss available options.
Order Tracking
- Once your order has shipped, you'll receive a shipping confirmation email with tracking information so you can monitor your delivery.
- Orders totaling $200 or more qualify for FREE UPS 2nd Day Air shipping within the continental United States.
- Free 2nd Day Air shipping does not apply to orders shipping to Puerto Rico, Hawaii, or Alaska.
Handled correctly, stability holds
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
Store vials in a cool, dry place away from heat and direct sunlight.
For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Frequently Asked Questions
PRODUCT & PURITY
This product is offered for laboratory and research use only. It is not intended for human consumption, medical use, therapeutic use, or veterinary use.
Yes, all of our products are sterile and sealed with a sterility plug and safety cap.
Our products undergo quality control internally at our lab and then 3rd party tested at Bioviridian (at their Texas facility) prior to shipment. All of our COA's are then posted on our site immediately upon receipt.
99% or higher. Period. The expected purity is listed on the individual product page or Certificate of Analysis, when available.
No. We are a manufacturing company and because these products are sold for research purposes only, we do not provide dosing, administration, or medical-use guidance.
Unless specifically stated otherwise, these products are not approved by the U.S. Food and Drug Administration for therapeutic or diagnostic use.
STORAGE & STABILITY
As a lyophilized powder, peptides are stable. Delays in shipments up to 7 days will have zero to minimal impact on efficacy of peptides. Most precautionary efforts must be made to maintain temperature consistency once reconstituted.
Store the product according to the storage recommendations provided on the label or accompanying documentation in your shipment. Proper storage helps maintain product integrity during its shelf life. Most peptides have an expiration date of 2 years if kept unreconstituted (lyophilized powder).
SHIPPING
Shipping times vary based on your location and the shipping method selected at checkout. We offer shipping options between 1 and 5 days.
No.
Once your order is processed, you will receive a shipping confirmation email with tracking information.
ORDERS
Each order includes the peptide vial as described on the product page above.
We accept all forms of credit cards and Zelle.
If your order has not yet been processed for shipment, we may be able to make changes. Please contact customer support as soon as possible after placing your order.
If your order arrives damaged or incorrect, contact our customer support team promptly at support@peaklabpeptides.com with your order number and photos of the package and product so we can assist you.
For the safety of our researchers and integrity of our products we can not accept returns whatsoever.
SUPPORT
If you have questions about your order or a product, please reach out through our customer support page or contact us at support@peaklabpeptides.com or call/text 605-524-2800.
Purity you can verify
TESTED
VERIFICATION
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
AVAILABILITY
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
Related Products
IGF-1 LR3 10-Vial Kit
IGF-1 LR3 10 Vial Kit
IGF-1 LR3 (Long Arg3 Insulin-Like Growth Factor-1) – 1mg (Lyophilized Peptide) 10 Vial Kit – For Research Use Only
IGF-1 LR3 is a synthetic analog of human Insulin-Like Growth Factor-1 (IGF-1), modified to extend its half-life in vitro through substitution of arginine at position 3 and removal of the first three amino acids of the native IGF-1 sequence. These modifications increase resistance to IGF-1 binding proteins, enhancing stability and prolonged activity in controlled research environments. Research has explored its role in cellular growth signaling, differentiation pathways, and IGF-1 receptor interaction mechanisms in laboratory models.
Product Details:
- Peptide: IGF-1 LR3 (Long Arg3 Insulin-Like Growth Factor-1)
- Sequence: 83 amino acids
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Quantity: 1mg per vial / 10 vials per kit
- Storage: Store lyophilized peptide at -4°F (-20°C). Once reconstituted, refrigerate at 36–46°F (2–8°C) and use within 30 days.
- Grade: For laboratory research use only. Not for human use, consumption, or therapeutic applications.
Potential Research Applications:
- IGF-1 receptor binding affinity and cellular signaling studies
- Cellular growth and differentiation pathway research
- Binding protein resistance and in vitro stability mechanism models
- Growth factor analog activity and structure-function investigations
For laboratory research only. This product is not intended to diagnose, treat, cure, or prevent any disease.
Ipamorelin 10-Vial Kit
Ipamorelin 10 Vial Kit
Ipamorelin – 5mg or 10mg (Lyophilized Peptide) 10 Vial Kit – For Research Use Only
Ipamorelin is a selective Growth Hormone Secretagogue (GHS) studied for its ability to stimulate endogenous growth hormone release through ghrelin receptor activation, without significantly affecting cortisol or prolactin levels in research models. Research has explored its activity in GH axis signaling, pituitary function, and endocrine pathway regulation in controlled laboratory environments. Ipamorelin is often examined alongside other GH-releasing peptides such as CJC-1295 No DAC in studies investigating synergistic effects on growth hormone pathway dynamics.
Product Details:
- Peptide: Ipamorelin
- Purity: >99%
- Form: Lyophilized powder
- Quantity: 5mg or 10mg per vial / 10 vials per kit
- Storage: Store at -4°F (-20°C). After reconstitution, refrigerate at 36–46°F (2–8°C) and use within 30 days.
- Grade: For research purposes only. Not for human consumption, therapeutic, or diagnostic use.
Potential Research Applications:
- Growth hormone secretion and GHS-R receptor activation studies
- GH axis signaling and pituitary function research
- Endocrine pathway regulation and GH secretagogue mechanism models
- Multi-peptide GH axis synergy investigations
For laboratory research only. This product is not intended to diagnose, treat, cure, or prevent any disease.
KPV 10-Vial Kit
KPV 10 Vial Kit
KPV – 10mg (Lyophilized Peptide) 10 Vial Kit – For Research Use Only
KPV (Lys-Pro-Val) is a naturally occurring tripeptide derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH), studied for its potential to modulate inflammatory signaling pathways and immune regulation in controlled laboratory environments. Research has explored its activity in epithelial barrier function, cytokine modulation, and localized inflammatory response mechanisms across multiple tissue types.
Product Details:
- Peptide: KPV (Lys-Pro-Val)
- Purity: >99%
- Form: Lyophilized powder
- Quantity: 10mg per vial / 10 vials per kit
- Storage: Store at -4°F (-20°C). After reconstitution, refrigerate at 36–46°F (2–8°C) and use within 30 days.
- Grade: For research purposes only. Not for human consumption, therapeutic, or diagnostic use.
Potential Research Applications:
- Inflammatory signaling pathway modulation studies
- Epithelial barrier function and mucosal tissue research
- Cytokine regulation and immune response mechanism models
- α-MSH derived peptide activity and receptor interaction investigations
For laboratory research only. This product is not intended to diagnose, treat, cure, or prevent any disease.
