Epithalon
Price range: $35.30 through $80.80
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99.8% — exceeds 99.00% minimum spec
- Batch
- ET-202604-001
- Test date
- April 30, 2026
- Method
- HPLC + MS
- Lab
-
Bioviridian
College Station, TX
Description
Epithalon Peptide– 10mg (Lyophilized Peptide) – For Research Use Only
Epithalon (also known as Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the naturally occurring pineal gland peptide Epithalamin. It is widely studied for its potential anti-aging, telomerase-activating, and longevity-enhancing effects. Research suggests that Epithalon may promote telomere extension, support circadian rhythm regulation, and improve oxidative stress resistance.
It is a popular compound in studies involving cellular aging, pineal gland function, and DNA repair mechanisms.
Product Details:
Peptide: Epithalon (Ala-Glu-Asp-Gly)
Purity: >98%
Form: Lyophilized powder
Quantity: 10mg per vial
Storage: Store at -4°F (-20°C). After reconstitution, refrigerate at 36–46°F (2–8°C) and use within 30 days.
Grade: For research purposes only. Not for human consumption, therapeutic, or diagnostic use.
Potential Research Applications:
Telomerase activation and cellular longevity studies
Anti-aging and pineal gland function research
Circadian rhythm and melatonin regulation studies
DNA repair and oxidative stress resistance models
For laboratory research only. This product is not intended to diagnose, treat, cure, or prevent any disease.
Epithalon peptide Details
Epithalon (also written Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled on epithalamin, a peptide preparation originally extracted from the bovine pineal gland by Russian researcher Vladimir Khavinson. Research on Epithalon has centered heavily on telomerase activation — several published studies report that the peptide can increase telomerase activity in human somatic cell lines, a mechanism directly tied to telomere length and cellular replicative capacity. Beyond telomere biology, Epithalon has been studied for its influence on the pineal gland's regulation of melatonin secretion and circadian rhythm, as well as broader endocrine and immune parameters in aging research models. It remains one of the most cited peptides within the Russian bioregulator research tradition, with published animal studies reporting effects on lifespan and age-related biomarkers, making it a frequent subject of longevity-focused peptide research programs.
Epithalon peptide Scientific Research
1. Telomerase Modulation and Longevity Models
Early experimental work in insects and rodents reported that Epithalon exposure could influence lifespan parameters in certain models. In fruit flies and rats, some studies observed a reduction in age-related mortality indices, and in specific mouse strains predisposed to cardiovascular and oncologic conditions, trends toward longer survival were reported under defined conditions.
Mechanistic investigations in human somatic cell cultures have suggested that Epithalon may:
- Activate telomerase in vitro
- Support telomere maintenance and reduce the accumulation of DNA replication–associated errors
- Potentially modulate the balance between cellular senescence and replicative capacity in experimental systems
In parallel, Epithalon has been examined for its ability to interact with oxidative stress pathways and free radical markers, which may contribute to observed longevity-related effects in certain preclinical models. These findings are preliminary and are not indicative of clinical anti-aging outcomes.
2. Epithalon and Gene Expression
Beyond telomerase, Epithalon appears to interact with the promoter regions of several genes in cell culture research, with reported influences on transcriptional activity. Experimental work has associated Epithalon with modulation of genes such as:
- CD5 – linked to immune cell differentiation and adaptive immune responses
- IL-2 – involved in T-cell regulation and broader white blood cell signaling
- MMP2 – associated with extracellular matrix remodeling, collagen dynamics, and tissue repair
- Tram1 – related to protein processing and transport
- Arylalkylamine-N-acetyltransferase (AANAT) – a key enzyme in melatonin synthesis
- pCREB-related targets – transcription factors involved in circadian signaling and potentially anti-neoplastic pathways
- Telomerase-associated components – consistent with observations on telomere biology
These gene-level interactions position Epithalon as a useful tool compound for studying how small peptides might influence transcriptional regulation in immune, connective, circadian, and genomic-maintenance pathways.
3. Skin and Extracellular Matrix Research
Epithalon has been studied in connective tissue and skin-related models focusing on fibroblast function and extracellular matrix integrity:
- Rodent studies indicate that Epithalon may increase fibroblast activation and proliferation parameters, with reported relative increases in fibroblast activity in certain skin models.
- Fibroblasts are central to collagen, elastin, and matrix protein production, making them a key focus in wound-repair and structural-aging research.
- Research has also suggested that Epithalon can influence apoptotic markers such as caspase-3 activity in fibroblast populations, potentially supporting cell survival in defined stress contexts.
These findings support the use of Epithalon as a probe for skin biology, wound-healing, and extracellular matrix maintenance in preclinical systems.
4. Tumor Growth, Circadian Genes, and Radiation Response
Epithalon has been evaluated in several experimental oncology models:
- In rodent tumor models, repeated Epithalon administration has been associated with slower tumor growth kinetics and reduced incidence of metastasis under specific conditions.
- Mechanistic work suggests that Epithalon may interact with circadian-related genes such as PER1, a clock gene that can be under-expressed in certain tumor contexts. Altered PER1 expression has been linked to changes in tumor behavior and sensitivity to external stressors.
- Experimental data indicate that increased PER1 expression may enhance the susceptibility of tumor cells to ionizing radiation, potentially affecting thresholds for radiation-induced cell death in in vitro and in vivo systems.
These observations are strictly preclinical and are used to explore how circadian gene regulation intersects with tumor biology and treatment-response research.
5. Epithalon, Melatonin, and Circadian Regulation
Because Epithalon is associated with pineal and circadian research, its impact on melatonin-related pathways has received particular attention:
- Rat studies suggest that Epithalon may influence both synthesis and release of melatonin by modulating AANAT and pCREB-related transcription factors, which play central roles in the melatonin production pathway.
- In primate models, Epithalon has been reported to normalize or modulate melatonin secretion patterns in age-related or experimentally altered conditions.
These findings support Epithalon’s use in circadian-rhythm and neuroendocrine research, especially where melatonin and day–night regulation are key endpoints.
6. Ocular / Retinal Models
Epithalon has also been tested in visual system research:
- In rodent models of retinal degeneration, Epithalon has been associated with preservation of retinal structure and improvement in electrophysiologic measures of retinal function in a subset of treated subjects.
- These experiments suggest that Epithalon may be useful in exploring mechanisms of photoreceptor preservation, retinal signaling, and neuroprotective strategies in the eye.
Again, these results are specific to experimental systems and do not imply established clinical efficacy.
Article Titles & Journals
- Open URLs for more info
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12411320/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12411320/
- https://pubmed.ncbi.nlm.nih.gov/12937682/
- https://pubmed.ncbi.nlm.nih.gov/12937682/
- https://pubmed.ncbi.nlm.nih.gov/35413689/
- https://pubmed.ncbi.nlm.nih.gov/35413689/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12356729/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12356729/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7037223/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7037223/
Fast, reliable shipping
We offer fast, reliable shipping through UPS and USPS.
Shipping Options
UPS shipping options include:
- Next Day Air
- 2nd Day Air
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Order Processing
- We ship Monday through Saturday.
- Orders placed before 6:00 PM EST / 3:00 PM PST are typically shipped the same day.
- Orders placed after the daily cutoff or on holidays will be processed on the next available shipping day.
Puerto Rico, Hawaii & Alaska
- Orders shipping to these destinations are sent via USPS unless alternative arrangements have been made in advance.
- Need a different shipping method? Contact us before placing your order so we can discuss available options.
Order Tracking
- Once your order has shipped, you'll receive a shipping confirmation email with tracking information so you can monitor your delivery.
- Orders totaling $200 or more qualify for FREE UPS 2nd Day Air shipping within the continental United States.
- Free 2nd Day Air shipping does not apply to orders shipping to Puerto Rico, Hawaii, or Alaska.
Handled correctly, stability holds
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
Store vials in a cool, dry place away from heat and direct sunlight.
For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Frequently Asked Questions
PRODUCT & PURITY
This product is offered for laboratory and research use only. It is not intended for human consumption, medical use, therapeutic use, or veterinary use.
Yes, all of our products are sterile and sealed with a sterility plug and safety cap.
Our products undergo quality control internally at our lab and then 3rd party tested at Bioviridian (at their Texas facility) prior to shipment. All of our COA's are then posted on our site immediately upon receipt.
99% or higher. Period. The expected purity is listed on the individual product page or Certificate of Analysis, when available.
No. We are a manufacturing company and because these products are sold for research purposes only, we do not provide dosing, administration, or medical-use guidance.
Unless specifically stated otherwise, these products are not approved by the U.S. Food and Drug Administration for therapeutic or diagnostic use.
STORAGE & STABILITY
As a lyophilized powder, peptides are stable. Delays in shipments up to 7 days will have zero to minimal impact on efficacy of peptides. Most precautionary efforts must be made to maintain temperature consistency once reconstituted.
Store the product according to the storage recommendations provided on the label or accompanying documentation in your shipment. Proper storage helps maintain product integrity during its shelf life. Most peptides have an expiration date of 2 years if kept unreconstituted (lyophilized powder).
SHIPPING
Shipping times vary based on your location and the shipping method selected at checkout. We offer shipping options between 1 and 5 days.
No.
Once your order is processed, you will receive a shipping confirmation email with tracking information.
ORDERS
Each order includes the peptide vial as described on the product page above.
We accept all forms of credit cards and Zelle.
If your order has not yet been processed for shipment, we may be able to make changes. Please contact customer support as soon as possible after placing your order.
If your order arrives damaged or incorrect, contact our customer support team promptly at support@peaklabpeptides.com with your order number and photos of the package and product so we can assist you.
For the safety of our researchers and integrity of our products we can not accept returns whatsoever.
SUPPORT
If you have questions about your order or a product, please reach out through our customer support page or contact us at support@peaklabpeptides.com or call/text 605-524-2800.
Purity you can verify
TESTED
VERIFICATION
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
AVAILABILITY
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
