KPV (Lysine-Proline-Valine)
Original price was: $56.00.$48.00Current price is: $48.00.
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99.7% — exceeds 99.00% minimum spec
- Batch
- KPV-202607-001
- Test date
- July 27, 2026
- Method
- HPLC + MS
- Lab
-
Bioviridian
College Station, TX
Description
KPV
KPV – 10mg (Lyophilized Peptide) – For Research Use Only
KPV (Lys-Pro-Val) is a naturally occurring tripeptide derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH), studied for its potential to modulate inflammatory signaling pathways and immune regulation in controlled laboratory environments. Research has explored its activity in epithelial barrier function, cytokine modulation, and localized inflammatory response mechanisms across multiple tissue types.
Product Details:
- Peptide: KPV (Lys-Pro-Val)
- Purity: >99%
- Form: Lyophilized powder
- Quantity: 10mg per vial
- Storage: Store at -4°F (-20°C). After reconstitution, refrigerate at 36–46°F (2–8°C) and use within 30 days.
- Grade: For research purposes only. Not for human consumption, therapeutic, or diagnostic use.
Potential Research Applications:
- Inflammatory signaling pathway modulation studies
- Epithelial barrier function and mucosal tissue research
- Cytokine regulation and immune response mechanism models
- α-MSH derived peptide activity and receptor interaction investigations
For laboratory research only. This product is not intended to diagnose, treat, cure, or prevent any disease.
KPV peptide Details
KPV is the C-terminal tripeptide fragment (Lysine-Proline-Valine) of alpha-melanocyte-stimulating hormone (α-MSH), isolated for research because it retains α-MSH's anti-inflammatory activity without the pigmentation or appetite-suppressing effects associated with the full-length hormone. Research has centered on KPV's interaction with inflammatory signaling pathways — notably NF-κB — and its effects in preclinical models of colitis, inflammatory bowel conditions, and skin inflammation, where it has been studied both systemically and topically. Because it is small enough to resist rapid degradation and appears to act independently of melanocortin receptor activation in several models, KPV is frequently referenced in gut-barrier and dermatological inflammation research as a peptide of interest for modulating localized immune-inflammatory tone without broad immunosuppression.
KPV peptide Scientific Research
- KPV and Oxidative Stress in Keratinocytes
Airborne particulate matter (PM), including fine PM10, is commonly used in vitro to model environmental stress on skin cells. In human HaCaT keratinocyte systems:
- PM10 exposure has been observed to reduce cell viability and increase cytotoxicity.
- This is typically accompanied by elevated reactive oxygen species (ROS) production and activation of stress-related signaling pathways.
When KPV was introduced into these models at specific concentrations (e.g., 50 μg/mL in reported studies):
- Keratinocyte viability appeared to be partially restored relative to PM10-only conditions.
- ROS levels were reduced compared to untreated PM10-exposed controls, suggesting that KPV may modulate redox-related pathways at the cellular level.
These outcomes are limited to controlled experimental systems and do not constitute established effects in human subjects.
- KPV and Inflammatory Signaling (IL-1β / NF-κB Axis)
PM10-challenged keratinocyte models often show an increase in pro-inflammatory mediators, including interleukin-1β (IL-1β):
- PM10 exposure can drive IL-1β secretion and activation of redox-sensitive transcription factors, such as nuclear factor-kappa B (NF-κB).
- This is associated with heightened inflammatory signaling and may contribute to various forms of cell stress and injury in vitro.
In the presence of KPV:
- Experimental data reported lower IL-1β secretion compared with PM10-exposed controls.
- KPV was associated with reduced NF-κB activation, consistent with dampening of specific redox-sensitive pathways.
These observations place KPV as a useful tool for dissecting how oxidative stress links to inflammatory transcriptional responses in skin-cell research models.
- KPV, Apoptosis Markers, and Cell-Fate Pathways
PM10 can trigger cell death programs, including apoptosis and pyroptosis, through ROS-mediated signaling and caspase activation. In HaCaT models:
- PM10 exposure elevates apoptosis-related markers, including Bax, Bcl-2 alterations, and cleaved caspase-3, alongside IL-1β changes.
- Caspase-1 activation is commonly explored as part of pyroptosis-related
When KPV was added in these experimental paradigms:
- Levels of ROS-associated caspase activity were reduced compared with PM10-only conditions.
- The expression of Bax, Bcl-2, cleaved caspase-3, and IL-1β was reported to be lower, consistent with a shift toward reduced apoptosis/pyroptosis signaling under the specific in vitro conditions tested.
These findings highlight KPV’s value as a research probe to understand how short peptides might intersect with stress-, apoptosis-, and pyroptosis-related pathways in keratinocytes.
- 3D Skin Models and Environmental Stress
Beyond monolayer cell culture, KPV has also been evaluated in three-dimensional (3D) skin models intended to more closely mimic epidermal architecture:
- PM10 exposure in 3D systems can induce inflammatory cell death and structural changes in the model tissue.
- KPV treatment, under defined experimental conditions, has been reported to attenuate markers of inflammatory cell death, supporting its use in advanced in vitro skin platforms.
These 3D data are exploratory but support the use of KPV in functional skin-model research, especially in projects focused on environmental pollutant responses, barrier integrity, and peptide-based modulation of stress pathways.
Article Titles & Journals
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- Free 2nd Day Air shipping does not apply to orders shipping to Puerto Rico, Hawaii, or Alaska.
Handled correctly, stability holds
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
Store vials in a cool, dry place away from heat and direct sunlight.
For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Frequently Asked Questions
PRODUCT & PURITY
This product is offered for laboratory and research use only. It is not intended for human consumption, medical use, therapeutic use, or veterinary use.
Yes, all of our products are sterile and sealed with a sterility plug and safety cap.
Our products undergo quality control internally at our lab and then 3rd party tested at Bioviridian (at their Texas facility) prior to shipment. All of our COA's are then posted on our site immediately upon receipt.
99% or higher. Period. The expected purity is listed on the individual product page or Certificate of Analysis, when available.
No. We are a manufacturing company and because these products are sold for research purposes only, we do not provide dosing, administration, or medical-use guidance.
Unless specifically stated otherwise, these products are not approved by the U.S. Food and Drug Administration for therapeutic or diagnostic use.
STORAGE & STABILITY
As a lyophilized powder, peptides are stable. Delays in shipments up to 7 days will have zero to minimal impact on efficacy of peptides. Most precautionary efforts must be made to maintain temperature consistency once reconstituted.
Store the product according to the storage recommendations provided on the label or accompanying documentation in your shipment. Proper storage helps maintain product integrity during its shelf life. Most peptides have an expiration date of 2 years if kept unreconstituted (lyophilized powder).
SHIPPING
Shipping times vary based on your location and the shipping method selected at checkout. We offer shipping options between 1 and 5 days.
No.
Once your order is processed, you will receive a shipping confirmation email with tracking information.
ORDERS
Each order includes the peptide vial as described on the product page above.
We accept all forms of credit cards and Zelle.
If your order has not yet been processed for shipment, we may be able to make changes. Please contact customer support as soon as possible after placing your order.
If your order arrives damaged or incorrect, contact our customer support team promptly at support@peaklabpeptides.com with your order number and photos of the package and product so we can assist you.
For the safety of our researchers and integrity of our products we can not accept returns whatsoever.
SUPPORT
If you have questions about your order or a product, please reach out through our customer support page or contact us at support@peaklabpeptides.com or call/text 605-524-2800.
Purity you can verify
TESTED
VERIFICATION
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
AVAILABILITY
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
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NAD+ is a naturally occurring coenzyme found in all living cells, studied for its fundamental role in cellular energy metabolism, mitochondrial function, and biochemical signaling pathways. Research models have explored its activity in sirtuin activation, DNA repair mechanisms, and oxidative stress response in controlled laboratory environments. Its role as a key coenzyme in redox reactions makes it a subject of significant interest in cellular biology and metabolic pathway research.
Product Details:
- Compound: NAD+ (Nicotinamide Adenine Dinucleotide)
- Purity: >99%
- Form: Lyophilized powder
- Quantity: 100mg, 500mg, or 1000mg per vial
- Storage: Store at -4°F (-20°C). After reconstitution, refrigerate at 36–46°F (2–8°C) and use within 30 days.
- Grade: For research purposes only. Not for human consumption, therapeutic, or diagnostic use.
Potential Research Applications:
- Mitochondrial function and cellular energy metabolism studies
- Sirtuin pathway activation and NAD+ dependent enzyme research
- DNA repair mechanism and oxidative stress response models
- Redox signaling and cellular biochemistry investigations
For laboratory research only. This product is not intended to diagnose, treat, cure, or prevent any disease.
