MOTS-c
Price range: $40.00 through $123.00
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99.8% — exceeds 99.00% minimum spec
- Batch
- MS-202607-001
- Test date
- July 23, 2026
- Method
- HPLC + MS
- Lab
-
Bioviridian
College Station, TX
Description
MOTS-c
MOTS-c – 10mg & 40mg (Lyophilized Peptide) – For Research Use Only
MOTS-c is a mitochondrial-derived peptide (MDP) encoded by the mitochondrial genome, studied for its potential role in metabolic pathway regulation, energy homeostasis, and cellular signaling. Research has explored its activity in glucose metabolism, insulin signaling pathways, and mitochondrial function in controlled laboratory environments. Its origin within the mitochondrial genome makes it a subject of significant interest in studies on mitochondrial biology and cellular energy regulation.
Product Details:
- Peptide: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)
- Purity: >98%
- Form: Lyophilized powder
- Quantity: 10mg or 40mg per vial
- Storage: Store at -4°F (-20°C). After reconstitution, refrigerate at 36–46°F (2–8°C) and use within 30 days.
- Grade: For research purposes only. Not for human consumption or therapeutic applications.
Potential Research Applications:
- Glucose metabolism and insulin signaling pathway studies
- Mitochondrial function and cellular energy regulation research
- Metabolic pathway modulation and energy homeostasis models
- Mitochondrial-derived peptide activity and cellular signaling investigations
For laboratory research use only. This product is not intended to diagnose, treat, cure, or prevent any disease.
MOTS-c Peptide​ Details
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial genome (specifically the 12S rRNA region), making it one of a small class of "mitochondrial-derived peptides" discovered through genomic research rather than classical protein prediction. Unlike nuclear-encoded metabolic hormones, MOTS-c appears to act as a direct signal from mitochondria to the nucleus, a communication axis researchers term "mitochondrial-nuclear retrograde signaling." Studies have focused on its ability to activate AMPK (5' AMP-activated protein kinase), a master regulator of cellular energy balance, and its downstream effects on glucose uptake, insulin sensitivity, and fatty-acid oxidation. Exercise physiology research has additionally explored circulating MOTS-c levels as a biomarker of physical exertion and mitochondrial capacity, fueling interest in the peptide's potential relevance to metabolic health and age-related decline in mitochondrial function.
Mots-c peptide​ Scientific Research
1. AMPK Activation & Metabolic Regulation
MOTS-c has been shown in preclinical studies to activate AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. AMPK activation helps promote glucose uptake, lipid oxidation, and improved mitochondrial efficiency in both in-vitro and in-vivo models.
2. Mitochondrial–Nuclear Signaling
MOTS-c is reported to translocate from mitochondria to the nucleus under stress conditions, influencing nuclear gene expression linked to metabolic regulation. This mitochondrial-nuclear crosstalk is a growing area of research in aging biology and cellular adaptation.
3. Stress Resistance & Longevity Pathways
Studies suggest MOTS-c enhances cellular resistance to metabolic stress by regulating redox balance, promoting mitochondrial biogenesis, and modulating stress-adaptive genes. It has been explored in models evaluating lifespan, exercise performance, and oxidative stress responses.
4. Obesity & Insulin Sensitivity Models
Preclinical studies have used MOTS-c in obesity and glucose metabolism models to examine its potential in modulating insulin sensitivity, weight regulation, and lipid metabolism. Results highlight its relevance in diabetes and metabolic disease frameworks.
5. Molecular Biomarker Profiling
Researchers use MOTS-c to analyze gene expression changes in metabolic pathways, focusing on AMPK targets, sirtuins, inflammatory cytokines, and mitochondrial dynamics proteins (e.g., PGC-1α, NRF1, TFAM) across tissues such as liver, muscle, and adipose.
Article Titles & Journals
- Exercise-Induced Muscle-Fat Crosstalk: Molecular Mediators and Their Pharmacological Modul
- Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism
- Circulating levels of MOTS-c in patients with breast cancer treated with metformin.
Fast, reliable shipping
We offer fast, reliable shipping through UPS and USPS.
Shipping Options
UPS shipping options include:
- Next Day Air
- 2nd Day Air
- 3 Day Select
- UPS Ground
Order Processing
- We ship Monday through Saturday.
- Orders placed before 6:00 PM EST / 3:00 PM PST are typically shipped the same day.
- Orders placed after the daily cutoff or on holidays will be processed on the next available shipping day.
Puerto Rico, Hawaii & Alaska
- Orders shipping to these destinations are sent via USPS unless alternative arrangements have been made in advance.
- Need a different shipping method? Contact us before placing your order so we can discuss available options.
Order Tracking
- Once your order has shipped, you'll receive a shipping confirmation email with tracking information so you can monitor your delivery.
- Orders totaling $200 or more qualify for FREE UPS 2nd Day Air shipping within the continental United States.
- Free 2nd Day Air shipping does not apply to orders shipping to Puerto Rico, Hawaii, or Alaska.
Handled correctly, stability holds
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
Store vials in a cool, dry place away from heat and direct sunlight.
For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Frequently Asked Questions
PRODUCT & PURITY
This product is offered for laboratory and research use only. It is not intended for human consumption, medical use, therapeutic use, or veterinary use.
Yes, all of our products are sterile and sealed with a sterility plug and safety cap.
Our products undergo quality control internally at our lab and then 3rd party tested at Bioviridian (at their Texas facility) prior to shipment. All of our COA's are then posted on our site immediately upon receipt.
99% or higher. Period. The expected purity is listed on the individual product page or Certificate of Analysis, when available.
No. We are a manufacturing company and because these products are sold for research purposes only, we do not provide dosing, administration, or medical-use guidance.
Unless specifically stated otherwise, these products are not approved by the U.S. Food and Drug Administration for therapeutic or diagnostic use.
STORAGE & STABILITY
As a lyophilized powder, peptides are stable. Delays in shipments up to 7 days will have zero to minimal impact on efficacy of peptides. Most precautionary efforts must be made to maintain temperature consistency once reconstituted.
Store the product according to the storage recommendations provided on the label or accompanying documentation in your shipment. Proper storage helps maintain product integrity during its shelf life. Most peptides have an expiration date of 2 years if kept unreconstituted (lyophilized powder).
SHIPPING
Shipping times vary based on your location and the shipping method selected at checkout. We offer shipping options between 1 and 5 days.
No.
Once your order is processed, you will receive a shipping confirmation email with tracking information.
ORDERS
Each order includes the peptide vial as described on the product page above.
We accept all forms of credit cards and Zelle.
If your order has not yet been processed for shipment, we may be able to make changes. Please contact customer support as soon as possible after placing your order.
If your order arrives damaged or incorrect, contact our customer support team promptly at support@peaklabpeptides.com with your order number and photos of the package and product so we can assist you.
For the safety of our researchers and integrity of our products we can not accept returns whatsoever.
SUPPORT
If you have questions about your order or a product, please reach out through our customer support page or contact us at support@peaklabpeptides.com or call/text 605-524-2800.
Purity you can verify
TESTED
VERIFICATION
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
AVAILABILITY
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
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CJC-1295 No DAC
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CJC-1295 No DAC – 5mg (Lyophilized Peptide) – For Research Use Only
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CJC-1295 No DAC is commonly studied in models focused on muscle growth, fat metabolism, anti-aging, and recovery when used alone or stacked with other GH secretagogues like Ipamorelin.
Product Details:
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Peptide: CJC-1295 No DAC
-
Purity: >98%
-
Form: Lyophilized powder
-
Quantity: 5mg per vial
-
Storage: Store at -4°F (-20°C). After reconstitution, refrigerate at 36–46°F (2–8°C) and use within 30 days.
-
Grade: For research purposes only. Not for human use, medical, or diagnostic applications.
Potential Research Applications:
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Growth hormone release studies
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Muscle growth and recovery models
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Anti-aging and longevity research
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Fat metabolism and body composition investigations
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 GLP-1 Tirz – 5mg (Lyophilized Peptide) – For Research Use Only
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KPV (Lysine-Proline-Valine)
KPV
KPV – 10mg (Lyophilized Peptide) – For Research Use Only
KPV (Lys-Pro-Val) is a naturally occurring tripeptide derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH), studied for its potential to modulate inflammatory signaling pathways and immune regulation in controlled laboratory environments. Research has explored its activity in epithelial barrier function, cytokine modulation, and localized inflammatory response mechanisms across multiple tissue types.
Product Details:
- Peptide: KPV (Lys-Pro-Val)
- Purity: >99%
- Form: Lyophilized powder
- Quantity: 10mg per vial
- Storage: Store at -4°F (-20°C). After reconstitution, refrigerate at 36–46°F (2–8°C) and use within 30 days.
- Grade: For research purposes only. Not for human consumption, therapeutic, or diagnostic use.
Potential Research Applications:
- Inflammatory signaling pathway modulation studies
- Epithelial barrier function and mucosal tissue research
- Cytokine regulation and immune response mechanism models
- α-MSH derived peptide activity and receptor interaction investigations
For laboratory research only. This product is not intended to diagnose, treat, cure, or prevent any disease.
