MOTS-c

• Peptide Type: Mitochondrial-Derived Peptide (MDP)
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Purity: ≥99% (HPLC-verified)
• Molecular Focus: Mitochondrial signaling, AMPK activation, energy regulation
• Applications: Aging research, metabolic stress response, mitochondrial homeostasis
• Format: Lyophilized peptide, 40mg vial
• Use Case: Laboratory research only

• Mitochondrial communication with the nucleus
• Regulation of cellular energy and nutrient sensing
• Systemic metabolic homeostasis

While originally believed to act only within mitochondria, MOTS-c has now been detected in the nucleus and in circulation, confirming its role as a bona fide hormone-like signaling molecule.

Key areas of research interest include:

• Metabolism and weight regulation
• Exercise capacity and fatigue resistance
• Insulin sensitivity and glucose handling
• Bone remodeling and osteoporosis models
• Longevity and age-related functional decline
• Cardiometabolic and vascular health

MOTS-c has become a focus of intensive metabolic and gerontology research over the last several years due to its potential to modulate energy pathways that were historically accessible mainly through dietary restriction or exercise.

1. AMPK Activation & Metabolic Regulation

MOTS-c has been shown in preclinical studies to activate AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. AMPK activation helps promote glucose uptake, lipid oxidation, and improved mitochondrial efficiency in both in-vitro and in-vivo models.

2. Mitochondrial–Nuclear Signaling

MOTS-c is reported to translocate from mitochondria to the nucleus under stress conditions, influencing nuclear gene expression linked to metabolic regulation. This mitochondrial-nuclear crosstalk is a growing area of research in aging biology and cellular adaptation.

3. Stress Resistance & Longevity Pathways

Studies suggest MOTS-c enhances cellular resistance to metabolic stress by regulating redox balance, promoting mitochondrial biogenesis, and modulating stress-adaptive genes. It has been explored in models evaluating lifespan, exercise performance, and oxidative stress responses.

4. Obesity & Insulin Sensitivity Models

Preclinical studies have used MOTS-c in obesity and glucose metabolism models to examine its potential in modulating insulin sensitivity, weight regulation, and lipid metabolism. Results highlight its relevance in diabetes and metabolic disease frameworks.

5. Molecular Biomarker Profiling

Researchers use MOTS-c to analyze gene expression changes in metabolic pathways, focusing on AMPK targets, sirtuins, inflammatory cytokines, and mitochondrial dynamics proteins (e.g., PGC-1α, NRF1, TFAM) across tissues such as liver, muscle, and adipose.

Q: What is MOTS-c primarily used for in research?
A: It is used to study mitochondrial signaling, AMPK activation, stress adaptation, and metabolic pathway regulation in aging and obesity models.

Q: Is MOTS-c a natural peptide?
A: Yes, MOTS-c is an endogenous peptide encoded in the mitochondrial genome, making it a naturally occurring component of cellular regulatory networks.

Q: Is MOTS-c suitable for human supplementation?
A: No. MOTS-c is strictly intended for in-vitro or in-vivo laboratory research and is not approved for human or therapeutic use.

Q: How does MOTS-c influence aging research?
A: MOTS-c has shown promise in preclinical aging models by promoting metabolic efficiency, enhancing resilience to oxidative stress, and modulating longevity-associated pathways.

Q: What’s the recommended storage for MOTS-c?
A: Store the lyophilized vial at -20°C. After reconstitution with sterile solvent, keep refrigerated and use within a few days under sterile lab protocols.