PT-141 10mg
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Description
PT-141 (Bremelanotide)
THIS IS NOT FOR HUMAN CONSUMPTION. SOLD FOR RESEARCH ONLY!
PT-141 peptide Details
PT-141 is a synthetic melanocortin receptor agonist derived from the analog Melanotan II. It primarily activates the MC3R and MC4R subtypes of the melanocortin receptor family, making it a valuable compound in studies of neuropeptide signaling, central nervous system modulation, and GPCR-targeted pharmacology. PT-141 is widely utilized in preclinical research to evaluate neuroendocrine function, sexual behavior pathways, and receptor selectivity.
This 10mg formulation is research-grade and prepared under stringent quality control conditions for laboratory use. It supports studies examining ligand–receptor dynamics, signaling cascade activation, and melanocortin-linked cellular responses.
About PT-141 peptide
- Structure: Synthetic cyclic heptapeptide related to Melanotan II
- Receptor Targeting: MC3R, MC4R (primary), with documented MC1R activity
- Primary Applications: GPCR activation, CNS signaling, inflammation modulation, pigmentation pathways
- Mechanism of Action: Triggers cAMP and ERK pathways via G-protein-coupled receptor binding
- Purity & Form: Lyophilized peptide, ≥99% HPLC-verified purity
PT-141 peptide Scientific Research
- Melanocortin Receptor Pharmacology
Used to investigate GPCR-mediated signaling, PT-141 allows researchers to explore agonist binding profiles, EC50 behavior, receptor desensitization, and second-messenger responses (e.g., cAMP, phospho-ERK). Its structure makes it suitable for receptor selectivity studies involving MC3R and MC4R. - Central Nervous System (CNS) Pathway Exploration
PT-141 is employed in rodent models to study hypothalamic signaling, neuromodulation, and neuroendocrine axis regulation. Experimental readouts include immediate early genes (IEGs), CREB activation, and behavioral assays linked to hypothalamic and limbic circuits. - Inflammatory Signaling & Immune Modulation
By targeting MC1R, PT-141 is also examined in immune cell models to evaluate macrophage phenotype modulation, cytokine expression profiles, and systemic inflammatory response markers. - Pigmentation & Melanocyte Function
In melanocyte-focused studies, PT-141 is used to map melanocortin pathway effects on melanin production, enzyme regulation, and UV-response signaling through cAMP/PKA/MAPK pathways.
PT-141 peptide FAQ
Q: What does PT-141 target in research studies?
A: It targets melanocortin receptors, primarily MC3R and MC4R, involved in CNS, neuroendocrine, and inflammatory signaling.
Q: Is PT-141 used for pigmentation studies?
A: Yes, its activity at MC1R supports studies in melanocyte biology and photobiology research.
Q: Is this the same compound as Bremelanotide?
A: Yes, PT-141 is the research name for Bremelanotide, studied for its melanocortin receptor agonist properties.
Q: What pathways does PT-141 activate?
A: It activates G-protein-coupled signaling cascades including cAMP accumulation and ERK/MAPK phosphorylation.
Q: What type of models is PT-141 used in?
A: Both in-vitro (cell-based) and in-vivo (rodent and animal) models exploring CNS, sexual behavior, inflammation, and receptor pharmacology.
Storage & Handling
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.- On arrival: Store vials in a cool, dry place away from heat and direct sunlight.
- Long-term (powder): For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
- After reconstitution: Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Note: Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Storage & Handling
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
- On arrival: Store vials in a cool, dry place away from heat and direct sunlight.
- Long-term (powder): For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
- After reconstitution: Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Note: Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
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