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99.8% — exceeds 99.00% minimum spec
- Batch
- G2-202607-001
- Test date
- July 23, 2026
- Method
- HPLC + MS
- Lab
-
Bioviridian
College Station, TX
Description
GHRP-2 Acetate peptide Details
GHRP-2 (pralmorelin) is a synthetic hexapeptide growth hormone secretagogue that activates the ghrelin/GHS receptor to stimulate pituitary GH release, distinguished in the research literature by its notably potent GH-releasing effect compared to other secretagogues. Unlike the more receptor-selective Ipamorelin, GHRP-2 produces a documented secondary rise in cortisol and prolactin alongside GH release — a pharmacological profile established in comparative secretagogue studies — making it a frequent reference point in research examining the relationship between secretagogue selectivity and downstream hormonal effects. GHRP-2 has an established clinical research history as a diagnostic agent for growth hormone deficiency testing, and continues to be studied in GH-axis research for its potent, rapid-onset secretagogue activity, often in direct comparison with more selective compounds to characterize the trade-off between GH-release potency and receptor selectivity.
GHRP-2 Acetate peptide Scientific Research
1. Muscle Structure and Protein Turnover
In livestock and large-animal models (including yaks), GHRP-2 has been investigated for its impact on muscle growth under nutritionally or environmentally challenging conditions:
- Protein Deposition and Degradation: Research indicates that GHRP-2 can improve net muscle protein balance by both increasing protein deposition and decreasing protein breakdown in skeletal muscle.
- Atrophy Pathways: GHRP-2 has been reported to downregulate atrogin-1 and MuRF1, key regulators in muscle proteolysis pathways associated with atrophy.
- Growth Plateaus: In conditions such as food deprivation, disease, or cold exposure, GHRP-2 has been observed to help overcome natural growth plateaus in certain models, suggesting a stabilizing effect on lean mass.
These findings make GHRP-2 a valuable experimental agent for studying catabolism, muscle preservation, and GH/IGF-1–linked anabolic signaling in adverse conditions.
2. Appetite and Energy Intake
GHRP-2 is also a probe compound for appetite regulation due to its interaction with ghrelin receptors:
- Experimental studies in rodents and humans have documented increased food intake following GHRP-2 exposure compared to placebo.
- This orexigenic effect is particularly relevant in research focused on chronic illness, cachexia, or other conditions where appetite and caloric intake are impaired.
By leveraging GHRP-2 in controlled settings, researchers can better understand ghrelin-like signaling and its role in energy balance.
3. Cardiac Cell Protection
Cardiac models have explored whether GHRP-2 and related peptides may influence cardiomyocyte survival:
- In cultured fetal heart cell lines, GHRP-2 and structurally related analogues have been associated with reduced apoptosis (programmed cell death) under stress conditions.
- Additional work with similar peptides (e.g., Hexarelin) suggests the existence of specific cardiac receptors or receptor complexes responsive to GHRP-like molecules.
These studies are mechanistic in nature and are used to probe protective signaling pathways in heart cells rather than to define clinical interventions.
4. Immune System and Thymic Function
GHRP-2 has been examined for its effects on the thymus and T-cell populations:
- The thymus, which plays a central role in T-cell maturation, functionally declines with age. GHRP-2 exposure in experimental models has been associated with increased thymic activity and improved output and diversity of T-cell subsets.
- Such changes may enhance adaptive immune responsiveness, tissue repair capacity, and immune surveillance in the models studied.
These observations make GHRP-2 a useful peptide for research into immune senescence and thymic rejuvenation.
5. Sleep Architecture and Sleep Quality
GHRP-2 has also been evaluated in sleep research:
- Controlled studies report that GHRP-2 may increase time spent in deeper sleep stages (stage 3 and 4 slow-wave sleep) and modestly enhance REM sleep duration.
- Experimental data suggest reduced deviations from “normal” sleep architecture, with associated improvements in metrics such as cognitive performance, blood pressure regulation, and perceived energy in study populations.
These findings position GHRP-2 as a tool for examining the relationship between GH secretagogues, sleep structure, and downstream physiological outcomes.
6. Pain Perception and Opioid Receptors
An intriguing line of research has explored the interaction between GHRP-2 and opioid-receptor systems:
- Initial animal models of osteoarthritis showed rapid reductions in pain-related behavior that occurred before structural joint changes, suggesting a direct neuromodulatory effect.
- Subsequent studies identified activity of GHRP-2 at opioid receptors, with evidence of selective receptor engagement.
This receptor selectivity may help inform future design of ligands that target analgesic pathways while minimizing typical opioid-related adverse effects in experimental models.
Article Titles & Journals
- Abundant expression of the membrane-anchored protease-regulator RECK in the anterior pitui
- Evaluation of Hypothalamic-Pituitary-Adrenal Axis by the GHRP2 Test: Comparison With the I
- The Safety and Efficacy of Growth Hormone Secretagogues.
- History to the discovery of ghrelin.
- Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient
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Handled correctly, stability holds
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
Store vials in a cool, dry place away from heat and direct sunlight.
For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Frequently Asked Questions
PRODUCT & PURITY
This product is offered for laboratory and research use only. It is not intended for human consumption, medical use, therapeutic use, or veterinary use.
Yes, all of our products are sterile and sealed with a sterility plug and safety cap.
Our products undergo quality control internally at our lab and then 3rd party tested at Bioviridian (at their Texas facility) prior to shipment. All of our COA's are then posted on our site immediately upon receipt.
99% or higher. Period. The expected purity is listed on the individual product page or Certificate of Analysis, when available.
No. We are a manufacturing company and because these products are sold for research purposes only, we do not provide dosing, administration, or medical-use guidance.
Unless specifically stated otherwise, these products are not approved by the U.S. Food and Drug Administration for therapeutic or diagnostic use.
STORAGE & STABILITY
As a lyophilized powder, peptides are stable. Delays in shipments up to 7 days will have zero to minimal impact on efficacy of peptides. Most precautionary efforts must be made to maintain temperature consistency once reconstituted.
Store the product according to the storage recommendations provided on the label or accompanying documentation in your shipment. Proper storage helps maintain product integrity during its shelf life. Most peptides have an expiration date of 2 years if kept unreconstituted (lyophilized powder).
SHIPPING
Shipping times vary based on your location and the shipping method selected at checkout. We offer shipping options between 1 and 5 days.
No.
Once your order is processed, you will receive a shipping confirmation email with tracking information.
ORDERS
Each order includes the peptide vial as described on the product page above.
We accept all forms of credit cards and Zelle.
If your order has not yet been processed for shipment, we may be able to make changes. Please contact customer support as soon as possible after placing your order.
If your order arrives damaged or incorrect, contact our customer support team promptly at support@peaklabpeptides.com with your order number and photos of the package and product so we can assist you.
For the safety of our researchers and integrity of our products we can not accept returns whatsoever.
SUPPORT
If you have questions about your order or a product, please reach out through our customer support page or contact us at support@peaklabpeptides.com or call/text 605-524-2800.
Purity you can verify
TESTED
VERIFICATION
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
AVAILABILITY
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
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- Grade: For research purposes only. Not for human consumption, therapeutic, or diagnostic use.
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- Storage: Store at -4°F (-20°C). After reconstitution, refrigerate at 36–46°F (2–8°C) and use within 30 days.
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- Mitochondrial function and cellular energy metabolism studies
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For laboratory research only. This product is not intended to diagnose, treat, cure, or prevent any disease.
