PNC-27
Price range: $79.00 through $126.00
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Description
PNC-27 is a synthetic 27-amino-acid peptide combining a p53-derived sequence with a membrane-penetrating domain, engineered to selectively target and disrupt cancer cell membranes through interaction with a form of the MDM2 protein expressed on the surface of cancerous — but not healthy — cells. Research on PNC-27 has focused on this selective cytotoxic mechanism: because many cancer cells display MDM2 on their outer membrane (unlike healthy cells, where MDM2 is intracellular), the peptide's membrane-penetrating domain is studied for its ability to induce direct membrane disruption specifically in MDM2-expressing cancer cells, triggering rapid cell death through a necrosis-like pathway distinct from the classical apoptosis mechanisms exploited by conventional chemotherapy. Published preclinical cell-culture and animal-model research has examined PNC-27's selective cytotoxicity across multiple cancer cell lines, making it a peptide of interest in targeted-cytotoxicity and cancer-cell-membrane research.
Mechanism of Action & Pathways
In experimental models, PNC-27 is studied for its interaction with HDM-2 localized at cancer cell membranes, enabling targeted association and membrane destabilization. Research focuses on how this interaction leads to pore formation, altered membrane integrity, and downstream signaling events associated with cell death in malignant cell lines.
Cellular & Molecular Research
PNC-27 is commonly utilized in laboratory studies examining:
- Peptide binding to cancer cell membranes
- Membrane permeability and pore formation assays
- p53-derived peptide structure–function relationships
All investigations are conducted in controlled in vitro or biochemical assay environments.
Oncology & Tumor-Selective Signaling Research
Research applications may include:
- Comparative studies between malignant and non-malignant cell membranes
- Apoptotic and necrotic signaling pathway analysis
- Evaluation of tumor-selective peptide activity in cellular models
These investigations remain exploratory and mechanistic, without therapeutic interpretation.
Experimental Models
- In vitro cancer cell membrane and viability assays
- Ex vivo tumor-derived tissue studies
- Non-clinical in vivo preclinical research models
All use is strictly limited to laboratory research contexts.
Article Titles & Journals
Fast, reliable shipping
We offer fast, reliable shipping through UPS and USPS.
Shipping Options
UPS shipping options include:
- Next Day Air
- 2nd Day Air
- 3 Day Select
- UPS Ground
Order Processing
- We ship Monday through Saturday.
- Orders placed before 6:00 PM EST / 3:00 PM PST are typically shipped the same day.
- Orders placed after the daily cutoff or on holidays will be processed on the next available shipping day.
Puerto Rico, Hawaii & Alaska
- Orders shipping to these destinations are sent via USPS unless alternative arrangements have been made in advance.
- Need a different shipping method? Contact us before placing your order so we can discuss available options.
Order Tracking
- Once your order has shipped, you'll receive a shipping confirmation email with tracking information so you can monitor your delivery.
- Orders totaling $200 or more qualify for FREE UPS 2nd Day Air shipping within the continental United States.
- Free 2nd Day Air shipping does not apply to orders shipping to Puerto Rico, Hawaii, or Alaska.
Handled correctly, stability holds
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
Store vials in a cool, dry place away from heat and direct sunlight.
For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Frequently Asked Questions
PRODUCT & PURITY
This product is offered for laboratory and research use only. It is not intended for human consumption, medical use, therapeutic use, or veterinary use.
Yes, all of our products are sterile and sealed with a sterility plug and safety cap.
Our products undergo quality control internally at our lab and then 3rd party tested at Bioviridian (at their Texas facility) prior to shipment. All of our COA's are then posted on our site immediately upon receipt.
99% or higher. Period. The expected purity is listed on the individual product page or Certificate of Analysis, when available.
No. We are a manufacturing company and because these products are sold for research purposes only, we do not provide dosing, administration, or medical-use guidance.
Unless specifically stated otherwise, these products are not approved by the U.S. Food and Drug Administration for therapeutic or diagnostic use.
STORAGE & STABILITY
As a lyophilized powder, peptides are stable. Delays in shipments up to 7 days will have zero to minimal impact on efficacy of peptides. Most precautionary efforts must be made to maintain temperature consistency once reconstituted.
Store the product according to the storage recommendations provided on the label or accompanying documentation in your shipment. Proper storage helps maintain product integrity during its shelf life. Most peptides have an expiration date of 2 years if kept unreconstituted (lyophilized powder).
SHIPPING
Shipping times vary based on your location and the shipping method selected at checkout. We offer shipping options between 1 and 5 days.
No.
Once your order is processed, you will receive a shipping confirmation email with tracking information.
ORDERS
Each order includes the peptide vial as described on the product page above.
We accept all forms of credit cards and Zelle.
If your order has not yet been processed for shipment, we may be able to make changes. Please contact customer support as soon as possible after placing your order.
If your order arrives damaged or incorrect, contact our customer support team promptly at support@peaklabpeptides.com with your order number and photos of the package and product so we can assist you.
For the safety of our researchers and integrity of our products we can not accept returns whatsoever.
SUPPORT
If you have questions about your order or a product, please reach out through our customer support page or contact us at support@peaklabpeptides.com or call/text 605-524-2800.
Purity you can verify
TESTED
VERIFICATION
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
AVAILABILITY
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
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- Grade: For research purposes only. Not for human consumption, therapeutic, or diagnostic use.
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