ACE-031
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Description
ACE-031 peptide Details
ACE-031 is a soluble, engineered form of the activin receptor type IIB (ActRIIB) extracellular domain, fused to an antibody Fc region to extend its circulating half-life. Functioning as a "decoy receptor," ACE-031 works by binding and sequestering myostatin (GDF-8) and related TGF-beta superfamily ligands before they can activate the native ActRIIB receptor on muscle cells — a mechanism that removes the brake myostatin normally places on muscle growth. Published preclinical research, including studies in non-human primates, documented substantial increases in muscle mass and strength following ACE-031 administration, and the compound advanced into human clinical trials for Duchenne muscular dystrophy before development was paused due to observed vascular side effects in that trial population. ACE-031 remains a frequently cited compound in myostatin-pathway and muscle-wasting disease research due to this well-documented clinical and preclinical dataset.
ACE-031 peptide Scientific Research
ACE-031 and Muscle Cells
In laboratory models, ACE-031 has been examined for its ability to interfere with myostatin signaling, a pathway associated with limiting muscle cell growth and differentiation. By binding myostatin and related ligands, ACE-031 is used to probe how reduced myostatin activity might affect:
- Muscle fiber size and lean mass in animal studies
- Muscle tissue volume (e.g., thigh muscle volume) over defined study periods
- Cross-talk between muscle cells, bone cells, and adipose tissue in complex metabolic models
Some preclinical experiments have reported increases in lean mass and regional muscle volume shortly after ACE-031 exposure, along with monitored changes in bone and fat-related markers. These observations are specific to controlled research systems and are not indicative of clinical performance.
ACE-031 and Energy Metabolism
Researchers have also used ACE-031 to investigate links between myostatin/ActRIIB signaling and muscle energy metabolism. Experimental work has assessed endpoints such as:
- Serum lactate concentrations and markers of metabolic stress
- Capillarization and vascular features within muscle tissue
- Indicators of oxidative damage and mitochondrial function
By blocking myostatin in these models, ACE-031 provides a platform for studying how altered signaling may influence fatigue-related parameters, oxidative balance, and oxygen delivery within skeletal muscle. These studies are mechanistic and are not designed to evaluate clinical outcomes.
ACE-031 and Muscle Force
Several preclinical studies have evaluated how ACE-031 exposure may influence muscle contractile properties. In these models, researchers have measured:
- Maximum force output and total contractile force of isolated muscles
- Thermodynamic variables, including oxidative respiration metrics
- ATP levels and indicators of contractile efficiency
Some reports describe increased force-generation metrics with relatively stable ATP and efficiency parameters, suggesting that myostatin pathway modulation can be used to explore the relationship between structural muscle changes and functional output in vitro and in vivo experimental systems.
ACE-031 and Muscle Repair
Muscle-wasting models, including those designed to mimic Duchenne Muscular Dystrophy (DMD) and related neuromuscular disorders, have been used to study ACE-031 as a myostatin-pathway probe. In these systems:
- Loss of functional dystrophin and elevated myostatin release from damaged fibers are key features
- Myostatin may influence surrounding muscle cells and contribute to ongoing atrophy
ACE-031 has been introduced in such research models to evaluate whether interference with myostatin signaling affects markers of muscle integrity, lean mass, and structural preservation. Investigators have monitored endpoints such as lean body mass, bone-related parameters, and adipose markers, but these results remain preliminary and confined to non-clinical contexts.
ACE-031 and Bone Density
The ActRIIB/myostatin axis is also implicated in bone turnover, leading to interest in ACE-031 as a tool compound in bone metabolism research. In certain animal models where ACE-031 was administered over several weeks, researchers have reported:
- Changes in total body weight and lean mass
- Increases in bone mineral density and bone mineral content
- Decreases in osteoclast populations and alterations in bone biomechanics, including stiffness and load-bearing capacity
Some data suggest substantial relative increases in bone mass and regional bone density (e.g., in the femur and vertebrae) in these models. These findings are experimental and are interpreted in the context of understanding bone remodeling pathways rather than as evidence of clinical benefit.
ACE-031 and Cancer-Associated Muscle Loss
Cancer cachexia and other malignancy-associated muscle-wasting phenomena are characterized by muscle fiber atrophy, altered mitochondrial function, and elevated oxidative stress. In such research settings, ACE-031 has been used to explore:
- Activation of signaling cascades such as the ERK1/2 pathway in muscle tissue
- Markers of apoptosis and muscle fiber atrophy
- Mitochondrial metabolism, ATP production, and free radical generation
Certain laboratory models have reported that modulation of myostatin/ActRIIB signaling with ACE-031 may influence these endpoints, leading to ongoing interest in its use as a research probe in cancer-related muscle loss. Additional exploratory work has examined how myostatin pathway interference may relate to insulin sensitivity, fat storage, tissue inflammation, and bone remodeling, all strictly within experimental contexts.
Article Titles & Journals
- ACE-031, a soluble activin type IIB receptor, increases muscle mass and strength in the co
- ACE-031, a Soluble Activin Type IIB Receptor, Increases Muscle Mass and Strength in the Co
- Gel Electrophoretic Detection of Black Market ACE-031.
- Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy:
- A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers.
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Handled correctly, stability holds
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
Store vials in a cool, dry place away from heat and direct sunlight.
For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Frequently Asked Questions
PRODUCT & PURITY
This product is offered for laboratory and research use only. It is not intended for human consumption, medical use, therapeutic use, or veterinary use.
Yes, all of our products are sterile and sealed with a sterility plug and safety cap.
Our products undergo quality control internally at our lab and then 3rd party tested at Bioviridian (at their Texas facility) prior to shipment. All of our COA's are then posted on our site immediately upon receipt.
99% or higher. Period. The expected purity is listed on the individual product page or Certificate of Analysis, when available.
No. We are a manufacturing company and because these products are sold for research purposes only, we do not provide dosing, administration, or medical-use guidance.
Unless specifically stated otherwise, these products are not approved by the U.S. Food and Drug Administration for therapeutic or diagnostic use.
STORAGE & STABILITY
As a lyophilized powder, peptides are stable. Delays in shipments up to 7 days will have zero to minimal impact on efficacy of peptides. Most precautionary efforts must be made to maintain temperature consistency once reconstituted.
Store the product according to the storage recommendations provided on the label or accompanying documentation in your shipment. Proper storage helps maintain product integrity during its shelf life. Most peptides have an expiration date of 2 years if kept unreconstituted (lyophilized powder).
SHIPPING
Shipping times vary based on your location and the shipping method selected at checkout. We offer shipping options between 1 and 5 days.
No.
Once your order is processed, you will receive a shipping confirmation email with tracking information.
ORDERS
Each order includes the peptide vial as described on the product page above.
We accept all forms of credit cards and Zelle.
If your order has not yet been processed for shipment, we may be able to make changes. Please contact customer support as soon as possible after placing your order.
If your order arrives damaged or incorrect, contact our customer support team promptly at support@peaklabpeptides.com with your order number and photos of the package and product so we can assist you.
For the safety of our researchers and integrity of our products we can not accept returns whatsoever.
SUPPORT
If you have questions about your order or a product, please reach out through our customer support page or contact us at support@peaklabpeptides.com or call/text 605-524-2800.
Purity you can verify
TESTED
VERIFICATION
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
AVAILABILITY
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
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Peptide Storage Case (3ml x 5 + Multi-Compartment) — Hard Shell Complete Organizer
An all-in-one solution for organizing your full research workflow.
This hard shell peptide storage case is designed to securely hold up to 5 standard 3ml vials, with additional dedicated compartments for other essential research materials. The precision-fit interior keeps every component stable and separated, so your full setup stays organized in a single case.
Built with a lightweight, impact-resistant shell and secure snap latches, this case is freezer and refrigerator safe — making it a reliable option for both at-home storage and on-the-go use.
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- Travel-friendly: Lightweight and easy to transport
The most complete option in our storage lineup, built for researchers who want everything organized in one place.
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