NAD+
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Description
NAD+ (Nicotinamide Adenine Dinucleotide)
THIS IS NOT FOR HUMAN CONSUMPTION. SOLD FOR RESEARCH ONLY!
NAD⁺ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme used in laboratory research to explore redox metabolism, mitochondrial energy production, and cellular aging mechanisms. Functioning as a pivotal electron transporter, NAD⁺ cycles between its oxidized (NAD⁺) and reduced (NADH) states to facilitate key biochemical pathways such as oxidative phosphorylation and glycolysis.
In addition to its metabolic roles, NAD⁺ acts as a substrate for regulatory enzymes like sirtuins and PARPs (poly ADP-ribose polymerases), which are involved in DNA repair, epigenetic regulation, and cellular stress responses. These functions make NAD⁺ a central molecule in anti-aging, neuroprotection, and metabolic resilience research. All uses are limited to non-clinical, in-vitro or in-vivo animal models.
- Molecule Type: Pyridine nucleotide coenzyme
- Forms: NAD⁺ (oxidized) and NADH (reduced)
- Primary Role: Redox electron transfer in cellular respiration
- Other Roles:
- DNA repair and genomic stability
- Epigenetic gene expression (via sirtuins)
- Immune signaling and oxidative stress modulation
- Research Use:
- Mitochondrial function assays
- Neurodegenerative model systems
- Metabolomics and transcriptomics profiling
- Aging and longevity investigations
- Note: Not for human consumption or clinical use. Supplied strictly for research purposes.
6 reviews for NAD+
1. Redox Biochemistry and Energy Metabolism
NAD⁺ is central to mitochondrial energy production, acting as an electron acceptor in the citric acid cycle, glycolysis, and oxidative phosphorylation. Its ratio with NADH serves as a readout for metabolic balance and cellular redox status in experimental systems.
2. Sirtuin and PARP Enzyme Studies
As a required substrate, NAD⁺ activates sirtuins (SIRT1–SIRT7) and PARP enzymes, key regulators of longevity, DNA repair, and apoptosis. Preclinical studies use NAD⁺ to quantify changes in gene expression, chromatin remodeling, and stress response markers.
3. Neurodegenerative and Anti-Aging Research
NAD⁺ is commonly studied in aging models for its role in neuronal protection, mitochondrial maintenance, and NAD⁺-dependent signaling. Restoration of NAD⁺ levels is correlated with improved cognitive performance, mitochondrial biogenesis, and decreased cellular senescence in animal models.
4. Metabolomic and Transcriptomic Profiling
High-throughput omics studies utilize NAD⁺ modulation to examine systemic changes in gene expression and metabolic pathways. This includes pathways associated with immune regulation, cellular repair mechanisms, and oxidative stress resilience.
Q: What is NAD⁺ used for in research?
A: NAD⁺ is used to investigate cellular energy metabolism, mitochondrial function, DNA repair, and aging mechanisms in preclinical studies.
Q: Is NAD⁺ the same as NADH?
A: No. NAD⁺ is the oxidized form, while NADH is the reduced form. Both are involved in redox reactions that power energy metabolism.
Q: Why is NAD⁺ important in anti-aging research?
A: NAD⁺ activates enzymes like sirtuins and PARPs that regulate DNA integrity, gene expression, and stress responses, which are critical for longevity studies.
Q: Can NAD⁺ be used in humans?
A: No. This product is strictly for research use in in-vitro or in-vivo experimental models and is not approved for human or clinical applications.
Q: What systems is NAD⁺ commonly studied in?
A: NAD⁺ is frequently examined in neurodegeneration, muscle metabolism, mitochondrial signaling, and metabolic syndrome models.
erimental design.
Storage & Handling
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
- On arrival: Store vials in a cool, dry place away from heat and direct sunlight.
- Long-term (powder): For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
- After reconstitution: Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Note: Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
Susan –
Very smooth purchasing experience with excellent product quality.
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Orders always arrive on time and in perfect condition.
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Clear product information and accurate descriptions.
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Fast processing and dependable shipping service.
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Customer service handled inquiries quickly and professionally.
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