Semax Nasal Spray
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Description
Semax
Semax – 5mg or 11mg (Lyophilized Peptide) – For Research Use Only
Semax is a synthetic peptide derivative of adrenocorticotropic hormone (ACTH 4-10) that has been extensively studied for its potential neuroprotective and cognitive-enhancing effects. Originally developed in Russia, Semax is believed to modulate brain-derived neurotrophic factor (BDNF) and influence neurotransmitter systems.
Product Details:
Compound: Semax
Purity: >98%
Form: Lyophilized powder
Quantity: 5mg or 11mg per vial
Storage: Store lyophilized at -20°C. Reconstituted product should be refrigerated (2–8°C) and used within 30 days.
Research Grade: For laboratory research only. Not for human consumption or therapeutic use.
Research Applications May Include: Studies on neuroprotection and cognitive function Exploration of BDNF modulation Investigations into stroke recovery and brain injury models
THIS IS NOT FOR HUMAN CONSUMPTION. SOLD FOR RESEARCH ONLY!
Semax Certificate of Analysis
Third-party tested. Click image to view full-resolution certificate.
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4–10) fragment, enhanced with a Pro-Gly-Pro stabilizing motif. It is commonly used in research examining central nervous system signaling, particularly through modulation of BDNF, TrkB receptors, and neurotrophin-regulated transcription factors such as NGF and GAP-43.
Semax has demonstrated neurotrophic, antioxidant, and monoaminergic effects in preclinical models, making it a popular peptide in experimental neuroscience for studies involving neuroplasticity, memory, stress response, and oxidative regulation. This formulation contains 11mg of lyophilized peptide, ideal for precision dilution and laboratory assay designs.
- Peptide Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
- Mechanism of Action: Enhances expression of BDNF, NGF, and other neurogenic genes via transcriptional regulation
- Pathway Targets: TrkB, MAPK/ERK, CREB, monoamine signaling
- Experimental Focus Areas: Learning & memory, oxidative stress, neurovascular modulation, transcriptional neurobiology
- Format: 11mg lyophilized powder, HPLC-verified purity ≥99%
- For Research Use Only: Not for human administration or clinical treatment
- Neurotrophin-Driven Gene Expression
Semax promotes expression of neurotrophic markers such as BDNF and NGF. Studies focus on hippocampal and cortical regions where BDNF/TrkB activity influences plasticity and cognitive function. - Cognitive and Memory Paradigms in Rodents
Used in learning and memory tasks (e.g., Morris water maze, T-maze), Semax has been evaluated for enhancing cognitive performance in aging or stress-exposed models. - CNS Systems-Level Imaging Studies
Functional and resting-state imaging has shown Semax's influence on connectivity and region-specific network activation in rodent brain studies. - Monoaminergic and Dopaminergic Modulation
Preclinical trials link Semax to regulation of serotonin and dopamine systems, with relevance to reward, motivation, and mood-linked behaviors. - Antioxidant and Cytoprotective Pathways
Semax has been studied for reducing lipid peroxidation and enhancing antioxidant enzyme expression in oxidative-stress models, particularly in brain and liver tissues. - Inflammation and Immune-Gene Modulation
Gene expression profiling in rodent studies indicates that Semax influences transcriptional activity in neuroimmune and neurovascular regulatory pathways.
Q: What is Semax commonly used for in research?
A: Semax is primarily used in neuroscience to study neuroplasticity, cognitive enhancement, neurotrophin signaling (e.g., BDNF), and transcriptional gene responses under stress or learning conditions.
Q: Does Semax influence mood or dopamine regulation?
A: Yes, research indicates Semax modulates monoaminergic signaling, especially dopamine and serotonin pathways, relevant to mood and behavioral regulation.
Q: How is Semax administered in studies?
A: It is commonly used in rodent studies via intranasal or subcutaneous routes. This 11mg vial is supplied in lyophilized form for precise reconstitution under laboratory protocols.
Q: Can Semax be used in human treatments or therapy?
A: No. This product is for preclinical laboratory research only. It is not approved for human consumption or therapeutic use.
Q: What makes Semax different from other ACTH analogs?
A: Its unique C-terminal PGP addition improves stability and CNS penetration while preserving neurotrophic effects, making it highly relevant for neurogenic and memory-related assays.
Storage & Handling
All peptides are supplied as sterile, lyophilized powder and are stable when handled correctly.
- On arrival: Store vials in a cool, dry place away from heat and direct sunlight.
- Long-term (powder): For optimal longevity, keep lyophilized peptides refrigerated to help maintain integrity.
- After reconstitution: Use an appropriate research diluent (for example, BAC water). Store the reconstituted solution in the refrigerator and use within 20–30 days for best stability.
Note: Minimize exposure to moisture and repeated freeze–thaw cycles. Follow your institution's safety procedures when handling research materials.
Peak Lab Peptides maintains quality-control processes and routinely performs third-party testing to support purity and identity verification. COAs are available upon request for applicable batches. Documentation may vary depending on production timelines.
We aim to make batch-level documentation available whenever possible. Our goal is to expand COA access across the full catalog as production capacity grows.
All products are for laboratory research use only and are not intended for human consumption.
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