TB-500 (Thymosin Beta-4 Fragment) 10 Vial Kit

TB-500 – 5mg (Lyophilized Peptide) 10 Vial Kit – For Research Use Only

TB-500 is a synthetic peptide corresponding to a 43-amino acid sequence of Thymosin Beta-4 (Tβ4), an actin-binding protein naturally distributed across mammalian tissues. It is one of the most widely studied regenerative research peptides in preclinical science, with a substantial body of literature examining its roles in cell migration, angiogenesis, cytoskeletal dynamics, and tissue repair signaling.

Chemical Profile

• Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
• Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
• Molecular Weight: 4,963 Da
• CAS Number: 77591-33-4
• Form: Lyophilized powder
• Purity: >99% (HPLC verified)
• Quantity: 5mg per vial / 10 vials per kit
• Storage: Store at -20°C long term / 4°C after reconstitution

TB-500 in Preclinical Research

Actin Binding and Cytoskeletal Dynamics TB-500's primary mechanism of interest involves its interaction with G-actin (globular actin), the monomeric form of actin that regulates filament assembly. By sequestering G-actin, TB-500 influences the G-actin/F-actin balance, which in turn affects cellular processes dependent on cytoskeletal remodeling including cell migration, membrane dynamics, and cytokinesis.

Cell Migration Research One of the most studied properties of TB-500 in preclinical systems is its role in promoting cell migration. Research has examined how TB-500's actin-modulating activity influences the motility of endothelial cells, keratinocytes, and fibroblasts — cell types central to tissue regeneration processes.

Angiogenesis Research TB-500 has been studied in the context of angiogenesis, the formation of new blood vessels from pre-existing vasculature. Preclinical models suggest it may influence VEGF-related transcriptional programs and endothelial cell behavior relevant to vascular repair and tissue perfusion research.

Tissue Repair and Wound Healing Models Multiple preclinical studies have examined TB-500 in wound healing models, investigating its effects on repair timelines, cellular recruitment, and extracellular matrix dynamics. A 2024 study identified TB-500 metabolites — particularly Ac-LKKTE — as potentially contributing to observed wound healing activity in vitro.

Inflammatory Signaling Research Preclinical research has investigated TB-500 in the context of inflammatory pathway modulation, examining its interactions with oxidative stress signaling and innate pathway nodes under experimentally defined stress conditions.

Cardiac and Vascular Research Emerging preclinical literature has studied TB-500 in cardiac tissue models, examining its potential interactions with cardiomyocyte survival signaling and vascular integrity mechanisms following experimental injury.

TB-500 vs BPC-157: Research Distinctions

TB-500 and BPC-157 are frequently studied together due to their complementary preclinical research profiles, but they have distinct molecular mechanisms:

Both are available individually or as the Wolverine Research Combo — BPC-157 and TB-500 bundled together for researchers studying complementary repair pathways.

Quality and Testing Standards

• HPLC Analysis — Confirms >99% purity
• Mass Spectrometry — Confirms correct peptide sequence and molecular identity
• Batch-Specific COA — Certificate of Analysis included with every order
• Third-Party Verified — Independent laboratory testing on every production run

Frequently Asked Questions

What is TB-500? TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4, an actin-binding protein studied for its roles in cell migration, angiogenesis, and tissue repair mechanisms in preclinical models.

What purity is Peak Lab Peptides TB-500? Our TB-500 is HPLC verified to >99% purity with mass spectrometry identity confirmation. Every batch includes a third-party Certificate of Analysis.

Is TB-500 the same as Thymosin Beta-4? TB-500 corresponds to a specific 43-amino acid sequence of Thymosin Beta-4 (Tβ4). It is a synthetic analog used in research to study the biological activity associated with the Tβ4 actin-binding domain.

How should TB-500 be stored? Store lyophilized TB-500 at -20°C for long-term stability. After reconstitution with bacteriostatic water, store at 4°C and use within 28 days.

What is the difference between TB-500 and BPC-157? TB-500 is primarily studied for actin-binding dynamics and cell migration mechanisms. BPC-157 is primarily studied for NO system modulation and VEGF signaling. Both are available as the Wolverine Research Combo for researchers studying complementary pathways.

For laboratory research use only. Not for human or veterinary use, consumption, or medical application.